Detailed information of TA system TA049320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 377417..377927
• Replicon: chromosome
• Accession: NZ_CP009610
• Organism: Haemophilus influenzae strain Hi375

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A2S9R6L1
• Locus tag: NF38_RS01820
• Protein ID: WP_038439526.1
• Coordinates: 377417..377638 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: NF38_RS01825
• Protein ID: WP_005650837.1
• Coordinates: 377631..377927 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NF38_RS01815	374365..377310	+	2946	WP_154231638.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
NF38_RS01820	377417..377638	+	222	WP_038439526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NF38_RS01825	377631..377927	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
NF38_RS01830	378111..380027	+	1917	WP_038440439.1	ABC transporter ATP-binding protein	-
NF38_RS01835	380037..380573	+	537	WP_011272152.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
NF38_RS01840	380589..381140	+	552	WP_011272151.1	threonylcarbamoyl-AMP synthase	-
NF38_RS01845	381144..381950	+	807	WP_011272150.1	shikimate dehydrogenase	-
NF38_RS01850	381962..382714	+	753	WP_011272149.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8804.33 Da
• Isoelectric Point: 10.7588

>T49320 WP_038439526.1 NZ_CP009610:377417-377638 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T49320 NZ_CP009610:377417-377638 [Haemophilus influenzae]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTCGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACTGCCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT49320 WP_005650837.1 NZ_CP009610:377631-377927 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT49320 NZ_CP009610:377631-377927 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A2S9R6L1