Detailed information of TA system TA049319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 322283..322887
• Replicon: chromosome
• Accession: NZ_CP009610
• Organism: Haemophilus influenzae strain Hi375

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8I2W3E0
• Locus tag: NF38_RS01575
• Protein ID: WP_038440394.1
• Coordinates: 322283..322591 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: NF38_RS01580
• Protein ID: WP_005661259.1
• Coordinates: 322591..322887 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NF38_RS01565	317396..318694	-	1299	WP_006995277.1	trigger factor	-
NF38_RS01570	319026..322226	+	3201	WP_154231637.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
NF38_RS01575	322283..322591	-	309	WP_038440394.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
NF38_RS01580	322591..322887	-	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
NF38_RS01585	323007..323861	-	855	WP_038440397.1	DUF3298 domain-containing protein	-
NF38_RS01590	323880..325739	-	1860	WP_038440399.1	selenocysteine-specific translation elongation factor	-
NF38_RS01595	325736..327121	-	1386	WP_038440401.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11885.59 Da
• Isoelectric Point: 7.3189

>T49319 WP_038440394.1 NZ_CP009610:c322591-322283 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLSLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T49319 NZ_CP009610:c322591-322283 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTATCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT49319 WP_005661259.1 NZ_CP009610:c322887-322591 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT49319 NZ_CP009610:c322887-322591 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2