Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1828595..1829570 Replicon chromosome
Accession NZ_CP009605
Organism Bacillus cereus strain S2-8

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BF33_RS09955 Protein ID WP_002036394.1
Coordinates 1828833..1829570 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BF33_RS09950 Protein ID WP_000588712.1
Coordinates 1828595..1828720 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF33_RS09920 1824298..1824918 - 621 WP_002036390.1 SGNH/GDSL hydrolase family protein -
BF33_RS09925 1825095..1825565 + 471 WP_000670597.1 DUF5065 family protein -
BF33_RS09930 1825800..1827269 - 1470 WP_000287523.1 beta-Ala-His dipeptidase -
BF33_RS31495 1827413..1827589 - 177 WP_000808045.1 hypothetical protein -
BF33_RS09940 1828024..1828305 + 282 WP_001041555.1 hypothetical protein -
BF33_RS31500 1828342..1828518 - 177 WP_000852612.1 hypothetical protein -
BF33_RS09950 1828595..1828720 - 126 WP_000588712.1 hypothetical protein Antitoxin
BF33_RS09955 1828833..1829570 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF33_RS09960 1829759..1830496 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF33_RS09965 1830664..1831146 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BF33_RS09970 1831253..1832938 + 1686 WP_002036395.1 alpha-keto acid decarboxylase family protein -
BF33_RS09975 1833060..1833370 - 311 Protein_1890 hypothetical protein -
BF33_RS09980 1833631..1834038 - 408 WP_000072501.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T49316 WP_002036394.1 NZ_CP009605:c1829570-1828833 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T49316 NZ_CP009605:c1829570-1828833 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT49316 WP_000588712.1 NZ_CP009605:c1828720-1828595 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT49316 NZ_CP009605:c1828720-1828595 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References