49315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1741749..1742388 Replicon chromosome
Accession NZ_CP009602
Organism Burkholderia thailandensis 2002721643

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag BG87_RS24155 Protein ID WP_009893919.1
Coordinates 1742209..1742388 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag BG87_RS24150 Protein ID WP_011401461.1
Coordinates 1741749..1742165 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG87_RS24140 1738845..1739579 + 735 WP_009893914.1 hypothetical protein -
BG87_RS32070 1739632..1740204 + 573 WP_009893915.1 site-specific integrase -
BG87_RS24145 1740823..1741320 + 498 WP_011401460.1 hypothetical protein -
BG87_RS24150 1741749..1742165 - 417 WP_011401461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG87_RS24155 1742209..1742388 - 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
BG87_RS24160 1742668..1743195 + 528 WP_011401462.1 PAAR domain-containing protein -
BG87_RS24165 1743192..1743926 + 735 WP_011401463.1 VRR-NUC domain-containing protein -
BG87_RS24170 1743936..1745051 + 1116 WP_009893924.1 DUF3396 domain-containing protein -
BG87_RS24175 1745122..1745697 - 576 WP_009893925.1 recombinase family protein -
BG87_RS32080 1746019..1746999 - 981 WP_043037760.1 DUF3644 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1741749..1761319 19570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T49315 WP_009893919.1 NZ_CP009602:c1742388-1742209 [Burkholderia thailandensis 2002721643]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T49315 NZ_CP009602:c1742388-1742209 [Burkholderia thailandensis 2002721643]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT49315 WP_011401461.1 NZ_CP009602:c1742165-1741749 [Burkholderia thailandensis 2002721643]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT49315 NZ_CP009602:c1742165-1741749 [Burkholderia thailandensis 2002721643]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
AlphaFold DB Q2T3Q7

References