49314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1064678..1066434 Replicon chromosome
Accession NZ_CP009602
Organism Burkholderia thailandensis 2002721643

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag BG87_RS21595 Protein ID WP_009900384.1
Coordinates 1065529..1066434 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag BG87_RS21590 Protein ID WP_009897321.1
Coordinates 1064678..1065532 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG87_RS21570 1059898..1061388 - 1491 WP_009897313.1 aldehyde dehydrogenase -
BG87_RS21575 1061410..1062225 - 816 WP_009897315.1 aspartate dehydrogenase -
BG87_RS21580 1062218..1063891 - 1674 WP_009897317.1 thiamine pyrophosphate-binding protein -
BG87_RS21585 1063884..1064681 - 798 WP_009897318.1 SDR family oxidoreductase -
BG87_RS21590 1064678..1065532 - 855 WP_009897321.1 IclR family transcriptional regulator Antitoxin
BG87_RS21595 1065529..1066434 - 906 WP_009900384.1 alpha/beta fold hydrolase Toxin
BG87_RS21600 1066451..1066978 - 528 WP_009897327.1 cupin domain-containing protein -
BG87_RS21605 1067017..1067787 - 771 WP_009897331.1 SDR family oxidoreductase -
BG87_RS21610 1067784..1068851 - 1068 WP_009897333.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BG87_RS21615 1068886..1069197 - 312 WP_009897334.1 hypothetical protein -
BG87_RS21620 1069199..1069516 - 318 WP_009897336.1 non-heme iron oxygenase ferredoxin subunit -
BG87_RS21625 1069951..1071039 + 1089 WP_009897338.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-285)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T49314 WP_009900384.1 NZ_CP009602:c1066434-1065529 [Burkholderia thailandensis 2002721643]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T49314 NZ_CP009602:c1066434-1065529 [Burkholderia thailandensis 2002721643]
ATGAGCGCAATCTCCACGACGACTACCGATGCGAGCGCGACGCCGTTCGCCGCGCTGCTCGAACGCTTTGCCGAGCGGCG
CGCGGCCGCAGGCGGCGCGCGTACGATCGGCTATCGCGAAGCGGGCGCAGCGTACGCAGCGCATGCCGGGCGCGATCCCG
TCGTGTTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCGCCGGGCTATGGCGTCTCGTCGCGCGTCGCGGCCGATTCGCCTGTCGCATCCGACTACGCGGCGTC
GCTCGCCGCGTGGCTCGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCG
CGTTCGCGCGGCAAGCGGGCGAGCGTCTTTCGGGATTGCTGCTGATTTCTCCGGCGGGCGGCTACGGCGGCGCACCCGCC
GACGTGCGGGCCGAGCGGCGCGACAGCCGCCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCAAACATGCTGTCCGCGCAGGCGAGCGACGCCGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCCG
GCTATGCGCAGGCGACGCACCTGCTCGCGAACGCGGACCTCGCGTCCGATCTCGCGCATTATCGCGGCCGCGTCGCGGTC
GCGGTCGGCGCCGACGATACGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGCGGGCAGCGGGCGCCGGGTTGCAGGT
GATCCCGCGCGCGGGCCATGCCGGCTATGTCGAAGCGCCGGATGCATACAACGCGTTGATCGACGCATTTTGCCGTCAAT
GCGACGGATCGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT49314 WP_009897321.1 NZ_CP009602:c1065532-1064678 [Burkholderia thailandensis 2002721643]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT49314 NZ_CP009602:c1065532-1064678 [Burkholderia thailandensis 2002721643]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGCGTAACGATTCGAACTACGTCGTGCCTGGGCTCGAGCGCGGGCT
GCGGATCCTCGCCGAGTTCTCGCCGCGCGAGCCAGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTGGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGTTTGCCGGTGATCGAGGG
CTTGCGCGACGCGACAGGCTTCACTGCGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCAAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGACGCTCGCGGAGTTGCGCACGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGATGCGCTGTTCGACGTGATCCGTGCCGACGCGCGCCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCAGTCGTCACGGTGACGGTGCCGAGG
CCGGAGATCGATGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTCGTGCGTGCGGCGGCCGAGCTGTCTCGGCGGCT
CAATTACCGGTCCGACGACGAAAACACCTACTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T555

Antitoxin

Source ID Structure
AlphaFold DB Q2T556

References