Detailed information of TA system TA049304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 108823..109798
• Replicon: chromosome
• Accession: NZ_CP009590
• Organism: Bacillus cereus G9241

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: AQ16_RS00910
• Protein ID: WP_033691453.1
• Coordinates: 109061..109798 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D8GY54
• Locus tag: AQ16_RS00905
• Protein ID: WP_000594608.1
• Coordinates: 108823..108948 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AQ16_RS00880	103844..104461	-	618	WP_142244172.1	SGNH/GDSL hydrolase family protein	-
AQ16_RS00885	104794..105453	-	660	WP_001979058.1	CatB-related O-acetyltransferase	-
AQ16_RS00890	105908..106366	+	459	Protein_106	DUF5065 family protein	-
AQ16_RS00895	106958..108427	-	1470	WP_001979053.1	beta-Ala-His dipeptidase	-
AQ16_RS31580	108571..108747	-	177	WP_000852618.1	hypothetical protein	-
AQ16_RS00905	108823..108948	-	126	WP_000594608.1	hypothetical protein	Antitoxin
AQ16_RS00910	109061..109798	-	738	WP_033691453.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
AQ16_RS00915	109987..110724	-	738	WP_001980023.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
AQ16_RS00920	110891..111373	-	483	WP_000191902.1	MarR family winged helix-turn-helix transcriptional regulator	-
AQ16_RS00925	111480..113165	+	1686	WP_001980021.1	alpha-keto acid decarboxylase family protein	-
AQ16_RS00930	113342..114124	-	783	WP_001980020.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28433.19 Da
• Isoelectric Point: 8.2672

>T49304 WP_033691453.1 NZ_CP009590:c109798-109061 [Bacillus cereus G9241]
VISNIRIGLFILVIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEVAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T49304 NZ_CP009590:c109798-109061 [Bacillus cereus G9241]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGTAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGTTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGTGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACTATGATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4878.27 Da
• Isoelectric Point: 3.9507

>AT49304 WP_000594608.1 NZ_CP009590:c108948-108823 [Bacillus cereus G9241]
VIKNNDNDFFKEDNEDTTDFSLIKGDTMQQVEDLEDELKRK

Nucleotide

• Length: 126 bp

>AT49304 NZ_CP009590:c108948-108823 [Bacillus cereus G9241]
GTGATAAAAAATAATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACGGATTTCTCGTTAATTAAAGGGGATAC
GATGCAGCAAGTAGAAGATTTAGAAGATGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U6H9M7