Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 753223..753878 Replicon chromosome
Accession NZ_CP009587
Organism Burkholderia mallei strain 11

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BG99_RS03475 Protein ID WP_004199884.1
Coordinates 753582..753878 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BG99_RS03470 Protein ID WP_004202809.1
Coordinates 753223..753579 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG99_RS03440 749355..750113 + 759 WP_004199892.1 cytochrome c1 -
BG99_RS03445 750206..750817 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BG99_RS03450 750887..751408 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BG99_RS03460 751630..752127 + 498 WP_004199888.1 terminase -
BG99_RS03465 752124..753179 + 1056 WP_004199886.1 phage portal protein -
BG99_RS03470 753223..753579 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BG99_RS03475 753582..753878 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG99_RS03485 754686..755806 + 1121 WP_038802950.1 IS3 family transposase -
BG99_RS33570 755834..755971 - 138 WP_004202832.1 hypothetical protein -
BG99_RS03490 755958..756398 - 441 WP_009935860.1 BPSL0067 family protein -
BG99_RS03495 756954..757418 + 465 WP_073699083.1 hypothetical protein -
BG99_RS03500 757754..758320 + 567 WP_004525805.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 751813..755806 3993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T49301 WP_004199884.1 NZ_CP009587:c753878-753582 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49301 NZ_CP009587:c753878-753582 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49301 WP_004202809.1 NZ_CP009587:c753579-753223 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49301 NZ_CP009587:c753579-753223 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References