Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1986509..1987550 | Replicon | chromosome |
| Accession | NZ_CP009585 | ||
| Organism | Burkholderia pseudomallei strain PHLS 112 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | DP45_RS09255 | Protein ID | WP_009972574.1 |
| Coordinates | 1986975..1987550 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A0E1SLI7 |
| Locus tag | DP45_RS09250 | Protein ID | WP_004540053.1 |
| Coordinates | 1986509..1986970 (+) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DP45_RS09230 | 1981613..1982212 | - | 600 | WP_076871524.1 | restriction endonuclease fold toxin 5 domain-containing protein | - |
| DP45_RS09240 | 1982554..1983060 | - | 507 | WP_076901090.1 | DUF4123 domain-containing protein | - |
| DP45_RS09245 | 1983057..1983479 | - | 423 | WP_012729878.1 | PAAR domain-containing protein | - |
| DP45_RS40350 | 1984176..1985006 | + | 831 | WP_198403620.1 | retron St85 family effector protein | - |
| DP45_RS32635 | 1984981..1985937 | + | 957 | WP_076886478.1 | retron St85 family RNA-directed DNA polymerase | - |
| DP45_RS09250 | 1986509..1986970 | + | 462 | WP_004540053.1 | excisionase family DNA-binding protein | Antitoxin |
| DP45_RS09255 | 1986975..1987550 | + | 576 | WP_009972574.1 | PIN domain-containing protein | Toxin |
| DP45_RS09260 | 1987783..1988751 | + | 969 | WP_139897735.1 | hypothetical protein | - |
| DP45_RS09265 | 1988952..1989944 | + | 993 | WP_009972572.1 | DUF3644 domain-containing protein | - |
| DP45_RS32645 | 1990171..1990410 | - | 240 | WP_076853220.1 | DNA mismatch repair protein | - |
| DP45_RS09270 | 1991247..1991426 | + | 180 | WP_004191077.1 | hypothetical protein | - |
| DP45_RS09275 | 1991610..1991882 | + | 273 | WP_004538129.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22124.51 Da Isoelectric Point: 6.2954
>T49296 WP_009972574.1 NZ_CP009585:1986975-1987550 [Burkholderia pseudomallei]
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIQVIELPDPDDRHVVAAAMYAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKAVEDYLDTMASQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIQVIELPDPDDRHVVAAAMYAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKAVEDYLDTMASQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T49296 NZ_CP009585:1986975-1987550 [Burkholderia pseudomallei]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGGACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCCAGGTGATCGAGCTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCTGCCATGTATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCTCAACATCCTGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAAGCGGTGGAAGACTATCTCGACACGATGGCCAGCCAAGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGGACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCCAGGTGATCGAGCTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCTGCCATGTATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCTCAACATCCTGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAAGCGGTGGAAGACTATCTCGACACGATGGCCAGCCAAGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17155.41 Da Isoelectric Point: 5.5474
>AT49296 WP_004540053.1 NZ_CP009585:1986509-1986970 [Burkholderia pseudomallei]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT49296 NZ_CP009585:1986509-1986970 [Burkholderia pseudomallei]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAAGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAACGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTAGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAAGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAACGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTAGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|