Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 937496..938125 Replicon chromosome
Accession NZ_CP009577
Organism Listeria ivanovii subsp. ivanovii strain WSLC 3010

Toxin (Protein)


Gene name pemK Uniprot ID A0A097BBV7
Locus tag JL52_RS04445 Protein ID WP_025279828.1
Coordinates 937778..938125 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G2ZDP2
Locus tag JL52_RS04440 Protein ID WP_014092317.1
Coordinates 937496..937774 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL52_RS04420 932836..934308 + 1473 WP_014092313.1 PH domain-containing protein -
JL52_RS04425 934429..935808 + 1380 WP_014092314.1 protoporphyrinogen oxidase -
JL52_RS04430 935810..936166 + 357 WP_014092315.1 holo-ACP synthase -
JL52_RS04435 936184..937290 + 1107 WP_014092316.1 alanine racemase -
JL52_RS04440 937496..937774 + 279 WP_014092317.1 CopG family ribbon-helix-helix protein Antitoxin
JL52_RS04445 937778..938125 + 348 WP_025279828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JL52_RS04450 938375..939211 + 837 WP_014092318.1 STAS domain-containing protein -
JL52_RS04455 939217..939573 + 357 WP_003721457.1 STAS domain-containing protein -
JL52_RS04460 939576..939986 + 411 WP_014092320.1 anti-sigma regulatory factor -
JL52_RS04465 940003..941007 + 1005 WP_025279829.1 PP2C family protein-serine/threonine phosphatase -
JL52_RS04470 941159..941503 + 345 WP_014092322.1 anti sigma b factor antagonist RsbV -
JL52_RS04475 941487..941960 + 474 WP_014092323.1 anti-sigma B factor RsbW -
JL52_RS04480 941938..942717 + 780 WP_014092324.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12829.90 Da        Isoelectric Point: 6.4735

>T49294 WP_025279828.1 NZ_CP009577:937778-938125 [Listeria ivanovii subsp. ivanovii]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMVKVNQALEVSLGVVEF

Download         Length: 348 bp

>T49294 NZ_CP009577:937778-938125 [Listeria ivanovii subsp. ivanovii]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGAAGCGAGCAAGGGGGAATACGGCCTGT
TCTCATCATTCAAAACGACATTGGTAATAGATTCAGCCCAACTGTGATTGTGGCAGCAATAACCGCAAAGATTCAAAAAG
CAAAGCTGCCAACACATGTGGAAGCTACTCGTAAAGATGGCTTTGAAAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACAATTGACAAACAACGCCTGACAGATAAGATTACACATTTGGACGAGGAACTAATGGTCAAGGTAAACCAGGCGCTGGA
AGTCAGTCTAGGAGTAGTAGAATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10621.13 Da        Isoelectric Point: 4.2980

>AT49294 WP_014092317.1 NZ_CP009577:937496-937774 [Listeria ivanovii subsp. ivanovii]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVES
EAEDRNISILGG

Download         Length: 279 bp

>AT49294 NZ_CP009577:937496-937774 [Listeria ivanovii subsp. ivanovii]
GTGTTAGAGAAAGAAAAGCGGATGATAATATCCGTAGAACTGACACAAGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAATTTTTGCAAGAGAAAAGGGCACGTGAGTTGA
GAGACGAGATGGAGCGCGGCTATGCGGAAATGGCGACAATTAACTTTGCTATCGCATGCGAGTGTACCCATGTCGAATCA
GAAGCAGAAGACAGAAATATTAGTATTTTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097BBV7

Antitoxin

Source ID Structure
AlphaFold DB G2ZDP2

References