49292

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 998774..999403 Replicon chromosome
Accession NZ_CP009575
Organism Listeria ivanovii subsp. londoniensis strain WSLC 30167

Toxin (Protein)


Gene name pemK Uniprot ID A0A097BBV7
Locus tag JL58_RS04650 Protein ID WP_025279828.1
Coordinates 999056..999403 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag JL58_RS04645 Protein ID WP_003761302.1
Coordinates 998774..999052 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL58_RS04625 994112..995584 + 1473 WP_003719081.1 PH domain-containing protein -
JL58_RS04630 995707..997086 + 1380 WP_038406968.1 protoporphyrinogen oxidase -
JL58_RS04635 997088..997444 + 357 WP_003719083.1 holo-ACP synthase -
JL58_RS04640 997462..998568 + 1107 WP_038408703.1 alanine racemase -
JL58_RS04645 998774..999052 + 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
JL58_RS04650 999056..999403 + 348 WP_025279828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JL58_RS04655 999653..1000489 + 837 WP_038406970.1 STAS domain-containing protein -
JL58_RS04660 1000495..1000851 + 357 WP_003719089.1 STAS domain-containing protein -
JL58_RS04665 1000854..1001264 + 411 WP_038406971.1 anti-sigma regulatory factor -
JL58_RS04670 1001281..1002285 + 1005 WP_038408704.1 PP2C family protein-serine/threonine phosphatase -
JL58_RS04675 1002435..1002779 + 345 WP_038406972.1 anti sigma b factor antagonist RsbV -
JL58_RS04680 1002763..1003236 + 474 WP_038406973.1 anti-sigma B factor RsbW -
JL58_RS04685 1003214..1003993 + 780 WP_038408706.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12829.90 Da        Isoelectric Point: 6.4735

>T49292 WP_025279828.1 NZ_CP009575:999056-999403 [Listeria ivanovii subsp. londoniensis]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMVKVNQALEVSLGVVEF

Download         Length: 348 bp

>T49292 NZ_CP009575:999056-999403 [Listeria ivanovii subsp. londoniensis]
CTGATGGTGAAGCGTGGTGACGTGTACTACGCGGACCTTTCCCCCGTGGTCGGAAGCGAGCAAGGGGGAATACGGCCTGT
TCTCATCATTCAAAACGACATTGGTAATAGATTCAGTCCAACTGTGATTGTGGCAGCAATAACCGCAAAAATTCAAAAAG
CAAAGTTGCCAACACATGTGGAAGCTACTCGTAAAGATGGCTTTGAAAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACAATTGACAAACAACGCCTGACAGATAAGATTACACATTTGGACGAGGAACTAATGGTCAAGGTAAACCAGGCGCTGGA
AGTCAGTCTAGGAGTAGTAGAATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT49292 WP_003761302.1 NZ_CP009575:998774-999052 [Listeria ivanovii subsp. londoniensis]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT49292 NZ_CP009575:998774-999052 [Listeria ivanovii subsp. londoniensis]
GTGTTAGAGAAAGAAAAGCGGATGATAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAATTTTTGCAAGAGAAAAGGGCACGTGAGTTGA
GAGACGAGATGGAGCGCGGCTATGCGGAGATGGCGACAATTAACTTTGCTATTGCATGCGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGACAGGAATATTAGTATATTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097BBV7

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References