Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1527028..1527656 Replicon chromosome
Accession NZ_CP009571
Organism Sphingomonas taxi strain ATCC 55669

Toxin (Protein)


Gene name vapC Uniprot ID A0A097EF51
Locus tag MC45_RS06850 Protein ID WP_038661137.1
Coordinates 1527028..1527435 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A097EF04
Locus tag MC45_RS06855 Protein ID WP_038661140.1
Coordinates 1527435..1527656 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC45_RS06830 1523127..1524161 + 1035 WP_038661128.1 acyltransferase -
MC45_RS06835 1524163..1524729 - 567 WP_038661131.1 DJ-1/PfpI/YhbO family deglycase/protease -
MC45_RS06840 1524748..1525857 + 1110 WP_169742526.1 DNA topoisomerase IB -
MC45_RS06845 1525869..1527077 + 1209 WP_052075547.1 mechanosensitive ion channel family protein -
MC45_RS06850 1527028..1527435 - 408 WP_038661137.1 tRNA(fMet)-specific endonuclease VapC Toxin
MC45_RS06855 1527435..1527656 - 222 WP_038661140.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MC45_RS06860 1528169..1531156 - 2988 WP_038661143.1 bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA -
MC45_RS06865 1531304..1531738 + 435 WP_169742563.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-116)

Antitoxin

SpoVT-AbrB domain

(7-32)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14844.96 Da        Isoelectric Point: 6.7157

>T49291 WP_038661137.1 NZ_CP009571:c1527435-1527028 [Sphingomonas taxi]
MLRYMLDTNLCIRVLRDRPQAVGERFNAEADGLSISTIVLTELLHGAVKSARPAENRRAVERFAARLEVLAFDAEAAAHA
GDIRATLEREGRSIGSYDVLIAGHARSRGLIVVTGNLGEFMRVDGLRCEDWLPAN

Download         Length: 408 bp

>T49291 NZ_CP009571:c1527435-1527028 [Sphingomonas taxi]
ATGCTGCGGTACATGCTCGATACCAATTTGTGCATCCGGGTGCTCCGCGATCGGCCGCAGGCGGTTGGCGAACGGTTCAA
TGCCGAAGCGGATGGCTTGTCGATCTCGACGATCGTGTTGACGGAATTGCTGCACGGCGCGGTCAAGTCGGCGCGTCCGG
CCGAGAACCGCCGCGCGGTGGAGCGATTTGCGGCGCGACTTGAGGTCTTGGCGTTCGATGCCGAGGCCGCGGCGCACGCT
GGCGATATCCGCGCCACGCTCGAACGTGAGGGGCGGTCGATCGGCAGCTATGACGTGCTGATTGCCGGCCATGCCCGCAG
CCGTGGCCTGATCGTCGTCACCGGCAACCTCGGCGAATTCATGAGGGTGGATGGTCTGCGTTGCGAGGATTGGCTGCCGG
CGAACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8297.32 Da        Isoelectric Point: 4.7719

>AT49291 WP_038661140.1 NZ_CP009571:c1527656-1527435 [Sphingomonas taxi]
MTRTSLFQSNRSQAVRLPKDVAFPEGVREVTILRDGVRRVIVPADRAWDDFFAAPGVELGEREQPEDQTREAL

Download         Length: 222 bp

>AT49291 NZ_CP009571:c1527656-1527435 [Sphingomonas taxi]
ATGACCCGTACGTCCCTGTTCCAGTCGAACCGGTCGCAGGCCGTGCGCCTCCCCAAGGATGTTGCGTTTCCCGAAGGCGT
TCGGGAAGTGACGATCCTGCGTGACGGGGTCCGGCGCGTGATCGTGCCGGCGGATCGGGCGTGGGACGATTTTTTCGCCG
CGCCGGGGGTGGAATTGGGCGAGCGCGAGCAGCCGGAGGATCAGACGCGCGAGGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097EF51

Antitoxin

Source ID Structure
AlphaFold DB A0A097EF04

References