Detailed information of TA system TA049280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1515472..1517252
• Replicon: chromosome
• Accession: NZ_CP009556
• Organism: Burkholderia oklahomensis C6786

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U4USQ6
• Locus tag: BG90_RS24605
• Protein ID: WP_010119621.1
• Coordinates: 1515472..1516821 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: BG90_RS24610
• Protein ID: WP_010109597.1
• Coordinates: 1516818..1517252 (-)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG90_RS24585	1510683..1512083	-	1401	WP_010119624.1	hypothetical protein	-
BG90_RS24590	1512508..1513461	-	954	WP_010109604.1	agmatinase	-
BG90_RS24595	1513614..1514528	+	915	WP_010119622.1	LysR family transcriptional regulator	-
BG90_RS24600	1514764..1515207	+	444	WP_010109600.1	hypothetical protein	-
BG90_RS24605	1515472..1516821	-	1350	WP_010119621.1	type II toxin-antitoxin system HipA family toxin	Toxin
BG90_RS24610	1516818..1517252	-	435	WP_010109597.1	helix-turn-helix domain-containing protein	Antitoxin
BG90_RS35650	1517323..1517523	-	201	WP_124072353.1	hypothetical protein	-
BG90_RS37050	1517560..1517768	-	209	Protein_1288	hypothetical protein	-
BG90_RS24615	1518225..1520597	+	2373	WP_107950947.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (12-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (22-71)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49795.74 Da
• Isoelectric Point: 9.0373

>T49280 WP_010119621.1 NZ_CP009556:c1516821-1515472 [Burkholderia oklahomensis C6786]
VSARRGTRTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPI
RRRIAMRYRTGGTSPFELLSTLGRDCVGALQMLPPGETPDDLERTRGRALADADIARLLREITSAPQAGQHEPLDDLRLS
IAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDDQKALV
VERFDRKPSSDARWILRLPQEDMCQATGTSAFDKYQADGGPGIEAIMDVLAGSEHAADRYAFFATQIVFWLLAATDGHAK
NFSIAHLPGNRFRSTPLYDVLSAHPVIGRGANQLPMQRARLAMGVRGKNIHYPINQIQRRHWIAQGQRVGFAPAEVDDMI
VALTARTAGVVDEVSARLPRDFPRDVADAVFSGMLRLNAKLAASSPARA

Nucleotide

• Length: 1350 bp

>T49280 NZ_CP009556:c1516821-1515472 [Burkholderia oklahomensis C6786]
GTGAGCGCGCGCCGCGGCACGCGCACGGCGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGC
CCGCGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCGCTGTCGCTTTCGCTGCCGT
TCACGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATC
CGGCGCCGGATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCTCGACGCTCGGCCGCGATTGCGT
CGGCGCGCTGCAGATGCTGCCGCCCGGCGAAACGCCGGACGATCTCGAGCGCACCCGCGGCCGCGCGCTCGCCGACGCGG
ACATCGCGCGCCTGCTGCGCGAGATCACGTCCGCGCCGCAAGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCG
ATCGCGGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGGTGGCTGCTGCCCGAAGGCAGCACGCCGACCAC
GCATATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGT
GCTCGAAGATCGTCGCCGCGTACGGGCTGCCCGTCGCGCATTGCGACATCGCGCATTTCGACGATCAGAAGGCGCTCGTC
GTCGAGCGCTTCGACCGCAAGCCGTCGAGCGACGCGCGCTGGATCCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGAC
GGGCACGTCCGCATTCGACAAATATCAGGCCGACGGCGGACCGGGCATCGAGGCGATCATGGACGTGCTCGCCGGCTCCG
AGCACGCGGCGGACCGCTACGCATTCTTCGCGACGCAAATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAG
AACTTCAGCATCGCGCATCTGCCGGGCAATCGCTTTCGATCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTGAT
CGGTCGGGGTGCCAATCAATTGCCGATGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGAACATCCACTATCCGA
TCAACCAGATCCAGCGGCGGCATTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGAGGTCGACGACATGATC
GTTGCATTGACCGCGCGAACCGCGGGCGTCGTCGACGAAGTGTCGGCGCGCCTGCCGCGCGATTTTCCGCGGGACGTCGC
CGATGCGGTCTTCAGCGGGATGCTGCGTCTGAACGCGAAGCTCGCCGCGTCATCGCCGGCGCGAGCGTAG

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15552.15 Da
• Isoelectric Point: 11.9043

>AT49280 WP_010109597.1 NZ_CP009556:c1517252-1516818 [Burkholderia oklahomensis C6786]
MAITIEHEIKTLGQLRPILRGFRKAAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTLTHVYVA
PAKPAAKQTVAAPARKAVKTVGSGRVAAKRPASPTSQSAPGPHAAERLPRSPRKRAAPKKREDW

Nucleotide

• Length: 435 bp

>AT49280 NZ_CP009556:c1517252-1516818 [Burkholderia oklahomensis C6786]
ATGGCCATCACCATCGAACACGAGATCAAGACGCTCGGCCAATTGCGGCCGATCCTGCGCGGCTTCCGCAAGGCGGCCGG
ATTGACGCAGGCGATGCTCGCGAGCCGCCTCGGCGTCACGCAGCAGACCTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTCCTCGATGTCGAACTCACGCTCACGCTGACCCATGTCTACGTCGCG
CCCGCCAAGCCCGCCGCGAAGCAGACGGTCGCCGCGCCCGCGCGCAAAGCCGTGAAAACGGTCGGAAGCGGACGCGTCGC
CGCAAAGCGCCCCGCGTCGCCGACGAGCCAATCCGCGCCCGGCCCGCATGCCGCCGAGCGCCTGCCCCGCTCGCCTCGCA
AGCGCGCCGCCCCGAAGAAGCGGGAGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4USQ6