Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2232165..2232679 Replicon chromosome
Accession NZ_CP009554
Organism Staphylococcus aureus strain FORC_001

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag FORC1_RS11260 Protein ID WP_000581791.1
Coordinates 2232165..2232374 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag FORC1_RS11265 Protein ID WP_000138934.1
Coordinates 2232386..2232679 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC1_RS11240 2228055..2229125 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
FORC1_RS11245 2229443..2230645 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FORC1_RS15585 2230806..2231489 - 684 Protein_2142 transposase -
FORC1_RS11255 2231901..2232037 - 137 Protein_2143 hypothetical protein -
FORC1_RS11260 2232165..2232374 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
FORC1_RS11265 2232386..2232679 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
FORC1_RS11270 2232845..2234329 + 1485 WP_000571560.1 cardiolipin synthase -
FORC1_RS11275 2234357..2235004 + 648 WP_001187612.1 HD domain-containing protein -
FORC1_RS15230 2235161..2235460 + 300 WP_001793952.1 hypothetical protein -
FORC1_RS11280 2235617..2236489 - 873 WP_000725802.1 membrane protein insertase YidC -
FORC1_RS11285 2236575..2237216 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T49274 WP_000581791.1 NZ_CP009554:c2232374-2232165 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T49274 NZ_CP009554:c2232374-2232165 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT49274 WP_000138934.1 NZ_CP009554:c2232679-2232386 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT49274 NZ_CP009554:c2232679-2232386 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References