Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 851636..852113 Replicon chromosome
Accession NZ_CP009554
Organism Staphylococcus aureus strain FORC_001

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC1_RS04085 Protein ID WP_000052076.1
Coordinates 851636..851824 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC1_RS04090 Protein ID WP_001059690.1
Coordinates 851853..852113 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC1_RS04055 847589..848146 + 558 WP_000824491.1 hypothetical protein -
FORC1_RS04060 848487..849173 + 687 WP_001574556.1 thermonuclease family protein -
FORC1_RS04065 849530..849730 + 201 WP_001059082.1 cold-shock protein -
FORC1_RS04070 850227..850445 - 219 WP_000005879.1 hypothetical protein -
FORC1_RS04075 850507..850791 - 285 WP_001004401.1 hypothetical protein -
FORC1_RS04080 850879..851448 - 570 WP_001106663.1 hypothetical protein -
FORC1_RS04085 851636..851824 - 189 WP_000052076.1 hypothetical protein Toxin
FORC1_RS04090 851853..852113 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC1_RS04095 852454..852657 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC1_RS04100 852654..852890 - 237 WP_000368687.1 hypothetical protein -
FORC1_RS04105 853115..853696 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
FORC1_RS04110 853769..854386 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
FORC1_RS04115 854542..855036 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC1_RS04120 855435..855857 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
FORC1_RS04125 856005..856721 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T49262 WP_000052076.1 NZ_CP009554:c851824-851636 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T49262 NZ_CP009554:c851824-851636 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT49262 WP_001059690.1 NZ_CP009554:c852113-851853 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT49262 NZ_CP009554:c852113-851853 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References