Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4110664..4112530 Replicon chromosome
Accession NZ_CP009553
Organism Pandoraea pnomenusa strain DSM 16536

Toxin (Protein)


Gene name doc Uniprot ID A0A378YWT3
Locus tag LV28_RS42330 Protein ID WP_038620228.1
Coordinates 4111604..4112530 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LV28_RS42325 Protein ID WP_162835271.1
Coordinates 4110664..4111602 (-) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV28_RS42305 4105895..4107391 - 1497 WP_038620232.1 aldehyde dehydrogenase -
LV28_RS42310 4107405..4108223 - 819 WP_038620230.1 aspartate dehydrogenase -
LV28_RS42315 4108216..4109868 - 1653 WP_023873356.1 thiamine pyrophosphate-binding protein -
LV28_RS42320 4109861..4110667 - 807 WP_023597209.1 SDR family oxidoreductase -
LV28_RS42325 4110664..4111602 - 939 WP_162835271.1 IclR family transcriptional regulator Antitoxin
LV28_RS42330 4111604..4112530 - 927 WP_038620228.1 alpha/beta fold hydrolase Toxin
LV28_RS42335 4112669..4113226 - 558 WP_023597212.1 cupin domain-containing protein -
LV28_RS42340 4113285..4114076 - 792 WP_023597213.1 SDR family oxidoreductase -
LV28_RS42345 4114093..4114875 - 783 WP_023597214.1 ABC transporter permease -
LV28_RS42350 4114916..4115785 - 870 WP_023597215.1 ABC transporter ATP-binding protein -
LV28_RS42355 4116111..4117187 - 1077 WP_031627377.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, C-terminal

(167-290)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31575.68 Da        Isoelectric Point: 6.2299

>T49261 WP_038620228.1 NZ_CP009553:c4112530-4111604 [Pandoraea pnomenusa]
MQAQANSSEVSEVSADADVPDVAALRARLAAFPYRTVTTRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALGLARVAVAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYT
AAKAGPVAVAVGAQDAVTPPASCQTIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T49261 NZ_CP009553:c4112530-4111604 [Pandoraea pnomenusa]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGCAGACGCCGATGTCCCCGATGTCGCCGCCCTGCGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCACCACGCGCGCGGGGACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCTGTGGTGATGCTGCACGGCATCGGGTCGGGGGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTACGCCGACGCCCTCGAAGCGTGGCTCGATGCGCTCGGTCTTGCGCGCGTGGCGGTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCCGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAC
GGCAAGGCCGACCCGGCAGTACGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACACG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCAGGATGCCGTCACCCCTCCCGCGAGCTGCCAGACGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCACGCGTCTTACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTTGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33953.70 Da        Isoelectric Point: 6.0582

>AT49261 WP_162835271.1 NZ_CP009553:c4111602-4110664 [Pandoraea pnomenusa]
MAPANPKRAVAAASIDDSTQDVQDMQDTLDDEVAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT49261 NZ_CP009553:c4111602-4110664 [Pandoraea pnomenusa]
ATGGCACCCGCCAATCCGAAGCGCGCCGTCGCCGCGGCGTCGATCGACGACAGCACGCAGGACGTACAGGACATGCAGGA
CACGCTGGACGACGAAGTCGCCGAGGCGGCGCCCGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACGTCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCCGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAACGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATAAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378YWT3

Antitoxin

Source ID Structure

References