Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2856826..2858546 Replicon chromosome
Accession NZ_CP009548
Organism Burkholderia sp. 2002721687

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U4SU12
Locus tag BW21_RS13240 Protein ID WP_006028959.1
Coordinates 2857197..2858546 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BW21_RS13235 Protein ID WP_006028958.1
Coordinates 2856826..2857200 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW21_RS13225 2852273..2853682 - 1410 WP_043283173.1 cellulase -
BW21_RS13230 2853687..2856011 - 2325 WP_006028957.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
BW21_RS13235 2856826..2857200 + 375 WP_006028958.1 helix-turn-helix domain-containing protein Antitoxin
BW21_RS13240 2857197..2858546 + 1350 WP_006028959.1 type II toxin-antitoxin system HipA family toxin Toxin
BW21_RS13245 2858574..2859110 - 537 WP_006028960.1 hypothetical protein -
BW21_RS13250 2859107..2860126 - 1020 WP_006028961.1 AAA family ATPase -
BW21_RS13255 2860267..2860716 - 450 WP_009915517.1 hypothetical protein -
BW21_RS13260 2860923..2861837 - 915 WP_006028963.1 LysR family transcriptional regulator -
BW21_RS13265 2861989..2862972 + 984 WP_006028964.1 agmatinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-71)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49632.56 Da        Isoelectric Point: 9.0228

>T49254 WP_006028959.1 NZ_CP009548:2857197-2858546 [Burkholderia sp. 2002721687]
VSARRARTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSPFELLATLGRDCVGALQMLPPDEAPDDLERIRGHALADADIARLLRDITSAPQAGEHEPLDDLRLSI
AGAQEKTALLRHRGRWLLPDGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDGQKALVV
ERFDRRPSSDARWILRLPQEDMCQATGTSALDKYQADGGPGIETIMGVLAGSERAADRYAFFAAQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGANRLPAQRARLAMGVRGKHVHYLIHQIQRRHWIAQGQRVGFAPAEVDDIIG
ALTARTEGVADEVSARLPRDFPMDVADAIFNGMRRLSAKLAAGAAARAS

Download         Length: 1350 bp

>T49254 NZ_CP009548:2857197-2858546 [Burkholderia sp. 2002721687]
GTGAGCGCGCGCCGCGCGCGCACCGCGCGCCTTCACCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCGCTGTCGCTGTCGCTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGC
CGGCGGATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAGGCGCCGGACGATCTCGAACGCATCCGCGGCCACGCGCTCGCCGATGCGGACA
TCGCACGCCTGCTGCGCGACATCACGTCCGCGCCGCAAGCCGGCGAGCACGAGCCGCTCGACGACCTGCGCCTGTCGATC
GCCGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGACGGCAGCACGCCGACCACGCA
CATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCT
CGAAGATCGTCGCCGCATACGGATTGCCGGTCGCGCATTGCGACATCGCGCATTTCGACGGCCAGAAGGCGCTCGTCGTC
GAGCGCTTCGACCGCAGGCCGTCGAGCGACGCGCGCTGGATTCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCAACCGG
CACGTCCGCGCTCGACAAATATCAGGCGGATGGCGGGCCGGGCATCGAGACGATCATGGGCGTGCTCGCCGGCTCCGAGC
GCGCGGCCGACCGCTACGCGTTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAAC
TTCAGCATCGCGCATCTGCCGGGCAACCGCTATCGATCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTGATCGG
CCGCGGGGCGAACCGGTTGCCGGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGCACGTCCATTACCTGATCC
ACCAGATCCAGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCGGCCGAAGTCGACGACATCATCGGC
GCGTTGACCGCGCGCACCGAGGGCGTCGCCGACGAAGTATCGGCCAGGCTGCCGCGAGATTTTCCGATGGACGTCGCCGA
TGCGATCTTCAACGGGATGCGTCGCCTGAGCGCGAAACTCGCGGCCGGCGCGGCCGCGCGAGCGTCGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13827.14 Da        Isoelectric Point: 11.8677

>AT49254 WP_006028958.1 NZ_CP009548:2856826-2857200 [Burkholderia sp. 2002721687]
MAIIIEHEIKTLDQLRPILRGFRKVAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTHVHTTSA
KQVVKQAAAPARKAANRPMPAPRAAERTPRPARKRAAPKQREDW

Download         Length: 375 bp

>AT49254 NZ_CP009548:2856826-2857200 [Burkholderia sp. 2002721687]
ATGGCCATCATCATCGAACACGAGATCAAGACGCTCGACCAATTGCGGCCCATCCTGCGAGGCTTCCGCAAGGTGGCCGG
ATTGACGCAAGCGATGCTCGCGAGCCGTCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTCCTCGACGTCGAGCTCACGCTGACCCACGTCCATACCACTTCCGCG
AAGCAAGTCGTCAAGCAGGCCGCCGCGCCCGCGCGCAAGGCCGCGAACCGGCCGATGCCCGCCCCGCGCGCCGCCGAGCG
CACGCCCCGCCCCGCGCGCAAGCGCGCCGCCCCGAAGCAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4SU12

Antitoxin

Source ID Structure

References