Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2265413..2266068 Replicon chromosome
Accession NZ_CP009548
Organism Burkholderia sp. 2002721687

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BW21_RS10715 Protein ID WP_006027262.1
Coordinates 2265413..2265709 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BW21_RS10720 Protein ID WP_004202809.1
Coordinates 2265712..2266068 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW21_RS10680 2260681..2260947 + 267 WP_006027268.1 ogr/Delta-like zinc finger family protein -
BW21_RS10685 2260944..2261150 + 207 WP_006027267.1 ogr/Delta-like zinc finger family protein -
BW21_RS10690 2261240..2261893 + 654 WP_009914986.1 AAA family ATPase -
BW21_RS10695 2262127..2262249 + 123 WP_009914987.1 hypothetical protein -
BW21_RS10700 2262352..2262885 + 534 WP_006027265.1 PAAR domain-containing protein -
BW21_RS10705 2262882..2263646 + 765 WP_006027264.1 VRR-NUC domain-containing protein -
BW21_RS10710 2263633..2264748 + 1116 WP_041861678.1 DUF3396 domain-containing protein -
BW21_RS10715 2265413..2265709 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BW21_RS10720 2265712..2266068 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BW21_RS10725 2266112..2267167 - 1056 WP_006027261.1 phage portal protein -
BW21_RS10730 2267164..2268933 - 1770 WP_006027260.1 terminase ATPase subunit family protein -
BW21_RS10735 2269077..2269886 + 810 WP_006027259.1 GPO family capsid scaffolding protein -
BW21_RS10740 2269931..2270941 + 1011 WP_006027258.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2248279..2292573 44294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T49253 WP_006027262.1 NZ_CP009548:2265413-2265709 [Burkholderia sp. 2002721687]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49253 NZ_CP009548:2265413-2265709 [Burkholderia sp. 2002721687]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATCGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49253 WP_004202809.1 NZ_CP009548:2265712-2266068 [Burkholderia sp. 2002721687]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49253 NZ_CP009548:2265712-2266068 [Burkholderia sp. 2002721687]
ATGAAAATCAGTGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAAGAAACAATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAATCCGCGCCTGATTCAAGCCGCGCTTGGGAACGTTGCGAAGGCGCGCGGCATGACGGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCGACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References