Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2089415..2091180 Replicon chromosome
Accession NZ_CP009548
Organism Burkholderia sp. 2002721687

Toxin (Protein)


Gene name doc Uniprot ID A0A7U4SUI5
Locus tag BW21_RS09910 Protein ID WP_006027423.1
Coordinates 2089415..2090329 (+) Length 305 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7U4PAC5
Locus tag BW21_RS09915 Protein ID WP_006027422.1
Coordinates 2090326..2091180 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW21_RS09880 2084810..2085898 - 1089 WP_009914825.1 porin -
BW21_RS09885 2086333..2086650 + 318 WP_009914826.1 non-heme iron oxygenase ferredoxin subunit -
BW21_RS09890 2086652..2086963 + 312 WP_006027427.1 hypothetical protein -
BW21_RS09895 2086998..2088065 + 1068 WP_006027426.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BW21_RS09900 2088062..2088832 + 771 WP_006027425.1 SDR family oxidoreductase -
BW21_RS09905 2088871..2089398 + 528 WP_009914832.1 cupin domain-containing protein -
BW21_RS09910 2089415..2090329 + 915 WP_006027423.1 alpha/beta fold hydrolase Toxin
BW21_RS09915 2090326..2091180 + 855 WP_006027422.1 IclR family transcriptional regulator Antitoxin
BW21_RS09920 2091177..2091974 + 798 WP_006027421.1 SDR family oxidoreductase -
BW21_RS09925 2091967..2093640 + 1674 WP_043282768.1 thiamine pyrophosphate-binding protein -
BW21_RS09930 2093633..2094448 + 816 WP_006027419.1 aspartate dehydrogenase -
BW21_RS09935 2094474..2095964 + 1491 WP_006027418.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-287)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 31147.07 Da        Isoelectric Point: 7.1483

>T49252 WP_006027423.1 NZ_CP009548:2089415-2090329 [Burkholderia sp. 2002721687]
MSAISTTTAGASAMPFAALLERFAERHAAAGDAGTIGYREAGESYGERTEQAGRDPVVLLHGIGSGAASWVRQLDALGAT
RRALAWDAPGYGASSRVAAGSPVAADYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARIASERLAGLLLISPAGGYGG
APADVRAERRDSRLALLASLGPQGLADERSANMLSAHASDTARAWVHWNMARIAPAGYAQAAHLLANADLASDLVHYRGR
VAVAVGGDDAITPPAACERIARAARVGLQVIPRAGHAGYVEAPDAYSALIDAFCRQCDGSRGAT

Download         Length: 915 bp

>T49252 NZ_CP009548:2089415-2090329 [Burkholderia sp. 2002721687]
ATGAGCGCGATTTCCACGACGACAGCCGGCGCGAGCGCGATGCCTTTCGCCGCGCTGCTCGAACGCTTCGCCGAGCGACA
CGCGGCGGCGGGCGACGCGGGCACGATCGGCTACCGCGAGGCGGGCGAATCGTACGGCGAGCGCACTGAGCAAGCCGGGC
GCGATCCCGTCGTGCTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCGACG
CGTCGCGCGCTCGCGTGGGACGCGCCAGGCTATGGCGCATCGTCACGCGTCGCGGCCGGCTCGCCCGTCGCGGCCGACTA
CGCGGCGTCGCTCGCCGCGTGGCTCGACGCGCTGCGCATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCG
TCGCCGGCGCGTTCGCGCGGATCGCGAGCGAGCGGCTTGCGGGATTGCTGCTGATTTCTCCTGCCGGCGGCTACGGCGGC
GCGCCCGCCGACGTGCGGGCCGAGCGGCGCGACAGCCGTCTCGCACTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGA
CGAGCGCAGCGCAAACATGTTGTCCGCGCATGCGAGCGACACGGCGCGCGCGTGGGTGCACTGGAACATGGCGCGCATCG
CGCCCGCCGGCTATGCGCAAGCGGCGCATCTGCTCGCGAACGCGGATCTCGCGTCCGATCTCGTCCATTACCGCGGCCGC
GTCGCGGTCGCCGTCGGCGGCGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATTGCGCGCGCGGCGCGTGTTGG
GCTGCAGGTGATTCCCCGTGCGGGCCATGCCGGCTACGTTGAAGCGCCCGATGCGTACAGCGCGTTGATCGACGCTTTTT
GCCGTCAATGTGACGGATCGCGAGGCGCGACATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31002.47 Da        Isoelectric Point: 7.4665

>AT49252 WP_006027422.1 NZ_CP009548:2090326-2091180 [Burkholderia sp. 2002721687]
MSEPLLKDADNAKNDSTYVVPGLERGLRVLAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVADGLIEKVVRAAGGLSRRLNYRADDENTYLKALGLR

Download         Length: 855 bp

>AT49252 NZ_CP009548:2090326-2091180 [Burkholderia sp. 2002721687]
ATGAGCGAACCGCTACTGAAAGACGCCGACAACGCGAAGAATGATTCGACCTACGTAGTACCGGGGCTCGAGCGCGGGCT
GCGGGTCCTGGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAGTCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAATTATCGCCTC
GGCGTCGCGGTGTTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACTGATCTCGGCTTGCCGGTGATAGAAGG
CTTGCGCGATGCGACGGGCTTCACGGCGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTATCCGGAGCGGGAGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACTGTCGACGCGCTCTTCGACGTGATTCGCGCCGATGCGCGGCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGATATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTCGTCGCCGACGGGCTGATCGAGAAGGTCGTGCGCGCGGCGGGCGGACTGTCGCGGCGGCT
CAACTACCGGGCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4SUI5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4PAC5

References