Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-Xre
Location 100523..101502 Replicon plasmid pBTU
Accession NZ_CP009547
Organism Burkholderia sp. 2002721687

Toxin (Protein)


Gene name ParT Uniprot ID A0A7U4P7N2
Locus tag BW21_RS00500 Protein ID WP_009917390.1
Coordinates 100523..101002 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID A0A7U4P7N6
Locus tag BW21_RS00505 Protein ID WP_006029252.1
Coordinates 100999..101502 (-) Length 168 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW21_RS35935 96550..97509 + 960 WP_141668135.1 hypothetical protein -
BW21_RS00485 97521..97808 + 288 WP_006029250.1 PAAR domain-containing protein -
BW21_RS35940 97964..98368 - 405 WP_144411843.1 hypothetical protein -
BW21_RS00495 98495..100120 + 1626 WP_043283261.1 hypothetical protein -
BW21_RS00500 100523..101002 - 480 WP_009917390.1 RES family NAD+ phosphorylase Toxin
BW21_RS00505 100999..101502 - 504 WP_006029252.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
BW21_RS00510 101569..103052 - 1484 Protein_107 site-specific integrase -
BW21_RS00515 103058..103882 - 825 WP_006029254.1 hypothetical protein -
BW21_RS00520 104066..104944 - 879 WP_006029255.1 3'-5' exonuclease -
BW21_RS32375 104990..105247 - 258 WP_080595248.1 hypothetical protein -
BW21_RS32380 105313..105654 - 342 WP_009917391.1 hypothetical protein -
BW21_RS00525 105635..105946 - 312 WP_009917392.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bspR2 / bspI2 1..305110 305110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-142)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(119-164)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17326.66 Da        Isoelectric Point: 5.6628

>T49250 WP_009917390.1 NZ_CP009547:c101002-100523 [Burkholderia sp. 2002721687]
MTVALWRIATDTPDYTADDLSGEGAKRTGGRWNRSGRAVLYTASNIALACLETVVHLSGGDLPLNRYLVRLEVPDEVWAK
ARTLDATSAPVGWDALPAGKVSLDLGDAWLSEGATALYCVPSVVVPEEVNVLINPAHLDTRHITATKLRRWTYDARVWA

Download         Length: 480 bp

>T49250 NZ_CP009547:c101002-100523 [Burkholderia sp. 2002721687]
ATGACGGTTGCGCTCTGGCGAATCGCAACCGACACGCCCGACTACACGGCGGACGACCTAAGCGGCGAAGGGGCGAAACG
CACCGGTGGTCGCTGGAACCGGTCGGGTCGCGCCGTGCTGTACACGGCCTCGAACATCGCGCTCGCCTGCCTCGAGACAG
TTGTTCATCTGAGCGGCGGAGACTTGCCACTCAACCGTTATCTGGTCCGCCTCGAGGTCCCCGACGAGGTGTGGGCGAAG
GCTCGCACCCTCGATGCGACATCGGCACCAGTGGGCTGGGACGCTTTGCCGGCCGGCAAGGTCAGTCTGGATCTCGGTGA
CGCGTGGCTGTCAGAGGGCGCTACCGCGCTGTACTGCGTGCCGTCGGTCGTCGTCCCGGAGGAGGTGAACGTGCTGATCA
ATCCCGCGCACCTGGATACGCGACACATCACTGCTACCAAGCTGCGCCGTTGGACCTATGACGCGCGCGTCTGGGCATAG

Antitoxin


Download         Length: 168 a.a.        Molecular weight: 18484.30 Da        Isoelectric Point: 9.6518

>AT49250 WP_006029252.1 NZ_CP009547:c101502-100999 [Burkholderia sp. 2002721687]
MSAIEKRHALPARARPRAVEPHELELLDFQRIYRASPMERIDWIKHGVDAHTVILLADRMATTQDRLMGVLGFPRTTVVR
KSKAKQPLSTEHTERVVGLSKLIGQVQSMVEESGEPAGFDAAHWVAQWIERTNPALGGRKPAELMDTVAGQELVGAVLAR
MQSGAYA

Download         Length: 504 bp

>AT49250 NZ_CP009547:c101502-100999 [Burkholderia sp. 2002721687]
ATGAGCGCGATCGAGAAACGACATGCCCTGCCTGCACGCGCGCGGCCGCGTGCGGTCGAGCCGCACGAGCTCGAATTGCT
CGACTTTCAGCGGATTTACCGCGCCTCGCCGATGGAACGTATTGACTGGATCAAGCATGGGGTCGACGCCCACACCGTGA
TTCTGCTCGCCGATCGCATGGCGACCACGCAGGACCGGCTCATGGGCGTCCTCGGATTTCCGCGAACGACGGTGGTCCGC
AAGTCGAAGGCAAAACAGCCGCTGTCAACCGAGCACACAGAGCGCGTTGTGGGCCTGTCGAAGCTGATCGGTCAGGTTCA
GTCTATGGTTGAGGAATCCGGCGAACCGGCCGGGTTCGACGCCGCTCATTGGGTCGCGCAGTGGATCGAGCGGACCAATC
CCGCTTTGGGTGGCCGCAAGCCGGCGGAATTGATGGATACCGTTGCAGGCCAGGAGCTCGTCGGCGCCGTGCTCGCACGG
ATGCAAAGCGGAGCATATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4P7N2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4P7N6

References