Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2383654..2384296 Replicon chromosome
Accession NZ_CP009541
Organism Bacillus anthracis str. Sterne

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag AW20_RS13455 Protein ID WP_000635963.1
Coordinates 2383654..2384004 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag AW20_RS13460 Protein ID WP_000004570.1
Coordinates 2384009..2384296 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AW20_RS13440 2380590..2381048 - 459 WP_000344248.1 SprT family protein -
AW20_RS13445 2381244..2381360 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
AW20_RS13450 2381418..2383586 - 2169 WP_000426225.1 RNA-binding transcriptional accessory protein -
AW20_RS13455 2383654..2384004 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AW20_RS13460 2384009..2384296 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
AW20_RS13465 2384606..2385775 - 1170 WP_000390596.1 alanine racemase -
AW20_RS13470 2385894..2386844 - 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
AW20_RS13475 2387001..2387360 - 360 WP_000635040.1 holo-ACP synthase -
AW20_RS13480 2387453..2388025 + 573 WP_000906916.1 rhomboid family intramembrane serine protease -
AW20_RS13485 2388018..2388980 - 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T49245 WP_000635963.1 NZ_CP009541:c2384004-2383654 [Bacillus anthracis str. Sterne]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T49245 NZ_CP009541:c2384004-2383654 [Bacillus anthracis str. Sterne]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT49245 WP_000004570.1 NZ_CP009541:c2384296-2384009 [Bacillus anthracis str. Sterne]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT49245 NZ_CP009541:c2384296-2384009 [Bacillus anthracis str. Sterne]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References