Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 308641..309616 Replicon chromosome
Accession NZ_CP009541
Organism Bacillus anthracis str. Sterne

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag AW20_RS02485 Protein ID WP_002036394.1
Coordinates 308879..309616 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag AW20_RS02480 Protein ID WP_000588712.1
Coordinates 308641..308766 (-) Length 42 a.a.

Genomic Context

AW20_RS02450AW20_RS02465AW20_RS02470AW20_RS02500AW20_RS02455AW20_RS31385AW20_RS31390AW20_RS02480AW20_RS02485AW20_RS02490AW20_RS02495AW20_RS02505
Location: 304395..304865 (471 bp)
Type: Others
Protein ID: WP_000670597.1
Location: 307557..307793 (237 bp)
Type: Others
Protein ID: WP_001021689.1
Location: 308070..308351 (282 bp)
Type: Others
Protein ID: WP_001041555.1
Location: 311299..312984 (1686 bp)
Type: Others
Protein ID: WP_009879073.1
Location: 305429..306898 (1470 bp)
Type: Others
Protein ID: WP_000287522.1
Location: 307042..307218 (177 bp)
Type: Others
Protein ID: WP_000808045.1
Location: 308388..308564 (177 bp)
Type: Others
Protein ID: WP_000852614.1
Location: 308641..308766 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 308879..309616 (738 bp)
Type: Toxin
Protein ID: WP_002036394.1
Location: 309805..310542 (738 bp)
Type: Others
Protein ID: WP_000594139.1
Location: 310710..311192 (483 bp)
Type: Others
Protein ID: WP_000191911.1
Location: 313106..313888 (783 bp)
Type: Others
Protein ID: WP_000381787.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AW20_RS02450304395..304865+471WP_000670597.1DUF5065 family protein-
AW20_RS02455305429..306898-1470WP_000287522.1beta-Ala-His dipeptidase-
AW20_RS31385307042..307218-177WP_000808045.1hypothetical protein-
AW20_RS02465307557..307793+237WP_001021689.1hypothetical protein-
AW20_RS02470308070..308351+282WP_001041555.1hypothetical protein-
AW20_RS31390308388..308564-177WP_000852614.1hypothetical protein-
AW20_RS02480308641..308766-126WP_000588712.1hypothetical proteinAntitoxin
AW20_RS02485308879..309616-738WP_002036394.1type II toxin-antitoxin system SpoIISA family toxinToxin
AW20_RS02490309805..310542-738WP_000594139.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
AW20_RS02495310710..311192-483WP_000191911.1MarR family winged helix-turn-helix transcriptional regulator-
AW20_RS02500311299..312984+1686WP_009879073.1alpha-keto acid decarboxylase family protein-
AW20_RS02505313106..313888-783WP_000381787.1class I SAM-dependent methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T49244 WP_002036394.1 NZ_CP009541:c309616-308879 [Bacillus anthracis str. Sterne]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T49244 NZ_CP009541:c309616-308879 [Bacillus anthracis str. Sterne]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT49244 WP_000588712.1 NZ_CP009541:c308766-308641 [Bacillus anthracis str. Sterne]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT49244 NZ_CP009541:c308766-308641 [Bacillus anthracis str. Sterne]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2R2IKP2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References