49242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 2648257..2649595 Replicon chromosome
Accession NZ_CP009539
Organism Yersinia ruckeri strain YRB

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag BD65_RS11945 Protein ID WP_042527234.1
Coordinates 2648257..2649207 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A845SFD2
Locus tag BD65_RS11950 Protein ID WP_042527235.1
Coordinates 2649200..2649595 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BD65_RS11930 2643540..2645977 - 2438 Protein_2329 type I restriction-modification system subunit M -
BD65_RS11935 2646017..2646256 - 240 WP_012543063.1 hypothetical protein -
BD65_RS11940 2646608..2647882 - 1275 WP_042527232.1 integrase arm-type DNA-binding domain-containing protein -
BD65_RS11945 2648257..2649207 - 951 WP_042527234.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BD65_RS11950 2649200..2649595 - 396 WP_042527235.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
BD65_RS16600 2649670..2649847 - 178 Protein_2334 DUF4942 domain-containing protein -
BD65_RS11955 2649883..2650968 - 1086 Protein_2335 IS3 family transposase -
BD65_RS11965 2651681..2652835 + 1155 WP_042528374.1 N-acetylneuraminate epimerase -
BD65_RS11970 2652883..2653575 + 693 WP_042527236.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2624307..2653575 29268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-303)

Antitoxin

Protein of unknown function DUF6088

(7-125)


Sequences

Toxin        


Download         Length: 317 a.a.        Molecular weight: 36023.51 Da        Isoelectric Point: 4.8000

>T49242 WP_042527234.1 NZ_CP009539:c2649207-2648257 [Yersinia ruckeri]
MDDLTKLFPDVADVLGIESVAIVEKDYYIVELLRLLQPLAFDTHQLVFAGGTALSKAGISLNRMSEYVDIKLVPVAGFSL
QYSRNQRKNIRKDIIKTITETIVASGMFSMDEEYPKVTRDENRYNEIPVRYPQKYAQAPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASVRNVERAVDESLVRHIYDNFCIVREKGADVPVLKLFV
QECIEQDIQRYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESHVSWEEAYTCFRKTVLDVVDA

Download         Length: 951 bp

>T49242 NZ_CP009539:c2649207-2648257 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCGGACGTTGCCGATGTTCTGGGCATTGAATCCGTTGCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTGCGATTGCTTCAGCCTCTGGCATTTGACACGCATCAACTGGTTTTTGCCGGTGGAACGGCAT
TGTCAAAAGCGGGGATATCTTTGAACAGGATGTCAGAATACGTGGACATTAAGCTTGTCCCCGTCGCCGGTTTTTCCCTG
CAATATTCCAGAAATCAACGCAAAAATATCCGTAAAGATATTATTAAGACCATCACCGAAACGATTGTAGCTTCAGGTAT
GTTTAGCATGGATGAGGAGTACCCAAAGGTTACTCGTGATGAAAACCGCTATAATGAGATTCCGGTGCGTTACCCGCAGA
AATATGCACAAGCTCCTTGCTTAAGGCCATTTATCAAACTGGAATTAATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCACTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTTCCCTGCGCAACTATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGCGTGCGTAATGTGGAGCGTGCAGTGGATGAGT
CACTGGTGCGTCATATCTACGACAACTTTTGTATTGTCAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCTCTTTGTG
CAGGAATGTATTGAGCAGGATATCCAACGTTACGGTGCTCAGTATCCTGAATTCTGCGAGTCGCCTGTTGAAGAACTAAA
AATGGGGTTGGAAGAACTGGCGAGCAACCCTGTTTATAAGGAACGCTATCTGCAGTTCGTCACACCAATGGTATTCGGTG
AAAGCCACGTTTCTTGGGAAGAGGCCTATACCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14379.65 Da        Isoelectric Point: 11.0360

>AT49242 WP_042527235.1 NZ_CP009539:c2649595-2649200 [Yersinia ruckeri]
MTTKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGNSKLNG

Download         Length: 396 bp

>AT49242 NZ_CP009539:c2649595-2649200 [Yersinia ruckeri]
ATGACCACAAAAGCTCGTATTCAGTCACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGATCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGTTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGCGATTACCGGTAAGCTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTAAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGTGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGAACATTATCAGTAGGGAACAGTAAATTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A845SFD2

References