49217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1968424..1969079 Replicon chromosome
Accession NZ_CP009535
Organism Burkholderia pseudomallei 7894

Toxin (Protein)


Gene name relE Uniprot ID A0A7U5JZW6
Locus tag BG97_RS08825 Protein ID WP_009969693.1
Coordinates 1968424..1968720 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U5K0U1
Locus tag BG97_RS08830 Protein ID WP_009969692.1
Coordinates 1968723..1969079 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG97_RS08805 1963820..1964248 + 429 WP_038722429.1 helix-turn-helix domain-containing protein -
BG97_RS33595 1964788..1965234 + 447 WP_076852949.1 MerR family transcriptional regulator -
BG97_RS08815 1965310..1965744 + 435 WP_143293234.1 hypothetical protein -
BG97_RS39815 1965757..1967076 + 1320 WP_143293235.1 hypothetical protein -
BG97_RS33600 1967077..1967814 + 738 WP_076852952.1 dCTP deaminase -
BG97_RS08825 1968424..1968720 + 297 WP_009969693.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG97_RS08830 1968723..1969079 + 357 WP_009969692.1 putative addiction module antidote protein Antitoxin
BG97_RS08835 1969123..1970178 - 1056 WP_009969691.1 phage portal protein -
BG97_RS08840 1970175..1971944 - 1770 WP_009969690.1 terminase ATPase subunit family protein -
BG97_RS08845 1972088..1972897 + 810 WP_009969689.1 GPO family capsid scaffolding protein -
BG97_RS08850 1972931..1973944 + 1014 WP_009969688.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1957767..1991660 33893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10888.66 Da        Isoelectric Point: 10.0996

>T49217 WP_009969693.1 NZ_CP009535:1968424-1968720 [Burkholderia pseudomallei 7894]
MYKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGRIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49217 NZ_CP009535:1968424-1968720 [Burkholderia pseudomallei 7894]
ATGTACAAAGTCCTGACGACCCCCCAATTTGACAAATGGCTTGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATCGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAGAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTGGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12671.50 Da        Isoelectric Point: 9.5609

>AT49217 WP_009969692.1 NZ_CP009535:1968723-1969079 [Burkholderia pseudomallei 7894]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEDGNAEFATIM
KVVGALGLHLTVAPVEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49217 NZ_CP009535:1968723-1969079 [Burkholderia pseudomallei 7894]
ATGAAAATCAGCGAACTGGCCGAGTTCGATGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAATCCGCGCCTGATTCAAGCCGCGCTTGGAAACGTTGCGAAGGCGCGCGGCATGACGGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGCGCGCTGTCGGAAGATGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACTTGACCGTTGCGCCGGTCGAACCTGCGCCGGTGCCCGCGCCGGCGACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5JZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5K0U1

References