49215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4549253..4549923 Replicon chromosome
Accession NZ_CP009533
Organism Pseudomonas rhizosphaerae strain DSM 16299

Toxin (Protein)


Gene name vapC Uniprot ID A0A089YT83
Locus tag LT40_RS20240 Protein ID WP_043193001.1
Coordinates 4549504..4549923 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A089YYV4
Locus tag LT40_RS20235 Protein ID WP_043193000.1
Coordinates 4549253..4549507 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT40_RS21770 4548744..4548920 + 177 WP_167335529.1 hypothetical protein -
LT40_RS20235 4549253..4549507 + 255 WP_043193000.1 plasmid stabilization protein Antitoxin
LT40_RS20240 4549504..4549923 + 420 WP_043193001.1 type II toxin-antitoxin system VapC family toxin Toxin
LT40_RS20245 4549993..4550364 - 372 WP_043193003.1 PH domain-containing protein -
LT40_RS20250 4550630..4553134 + 2505 WP_043193005.1 membrane-targeted effector domain-containing toxin -
LT40_RS20255 4553458..4554831 + 1374 WP_043193006.1 multicopper oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4541660..4549923 8263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15104.58 Da        Isoelectric Point: 5.6489

>T49215 WP_043193001.1 NZ_CP009533:4549504-4549923 [Pseudomonas rhizosphaerae]
MILLDTNVISEPLRHSPEACVIRWIDEQALETLYLSAMTVAELRAGIALMPVGRRRSTLHESLEKQVLPMFVGRVLAFDL
ACTQAYAEVLSKARKSGSGIEAADACIAAVALANGFIVATRDTHPFRAAGLTVIDPWEL

Download         Length: 420 bp

>T49215 NZ_CP009533:4549504-4549923 [Pseudomonas rhizosphaerae]
ATGATCCTGCTCGATACGAATGTGATTTCCGAGCCTCTACGTCATTCGCCTGAGGCGTGCGTCATTCGGTGGATCGATGA
GCAGGCATTGGAAACCCTTTACCTGTCCGCCATGACCGTGGCTGAGCTACGTGCAGGTATAGCGTTGATGCCGGTTGGGC
GACGTCGTTCGACGCTGCACGAAAGTCTAGAAAAGCAGGTGCTGCCCATGTTCGTCGGACGCGTTCTAGCTTTTGATCTG
GCCTGTACACAGGCTTACGCCGAAGTGCTGAGCAAGGCGCGCAAATCCGGTAGTGGGATTGAGGCTGCCGATGCGTGCAT
CGCTGCGGTCGCCCTTGCCAATGGATTCATCGTCGCCACGCGCGATACACACCCGTTCCGGGCCGCCGGCCTGACGGTCA
TCGATCCTTGGGAGCTGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.74 Da        Isoelectric Point: 10.5767

>AT49215 WP_043193000.1 NZ_CP009533:4549253-4549507 [Pseudomonas rhizosphaerae]
MPSVTVRNVSDEVHRAIRVRAAQHGRSIEAEMREILESAVKPERRIKLGSLLAQTGRKVKLTDEEFASFESARDKAPARA
VSFE

Download         Length: 255 bp

>AT49215 NZ_CP009533:4549253-4549507 [Pseudomonas rhizosphaerae]
ATGCCATCCGTTACCGTTCGAAATGTTTCTGATGAGGTACATCGTGCTATCCGTGTGCGGGCCGCTCAACATGGCCGCAG
CATCGAAGCCGAGATGCGTGAAATTCTCGAGTCTGCCGTAAAGCCGGAACGTCGGATTAAGCTCGGCTCGCTGCTGGCCC
AGACCGGCCGCAAGGTCAAGTTGACGGATGAAGAGTTTGCTAGCTTCGAAAGCGCACGCGATAAAGCCCCCGCCCGCGCG
GTGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089YT83

Antitoxin

Source ID Structure
AlphaFold DB A0A089YYV4

References