Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-UPF0150 |
| Location | 1837490..1837933 | Replicon | chromosome |
| Accession | NZ_CP009505 | ||
| Organism | Methanosarcina sp. MTP4 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A0E3NW26 |
| Locus tag | MSMTP_RS07810 | Protein ID | WP_048178533.1 |
| Coordinates | 1837709..1837933 (+) | Length | 75 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A0E3NWF4 |
| Locus tag | MSMTP_RS07805 | Protein ID | WP_048178532.1 |
| Coordinates | 1837490..1837708 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MSMTP_RS07800 (MSMTP_1423) | 1835545..1837083 | + | 1539 | WP_048178531.1 | FG-GAP-like repeat-containing protein | - |
| MSMTP_RS07805 (MSMTP_1424) | 1837490..1837708 | + | 219 | WP_048178532.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MSMTP_RS07810 (MSMTP_1425) | 1837709..1837933 | + | 225 | WP_048178533.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MSMTP_RS19695 (MSMTP_1426) | 1838449..1839711 | + | 1263 | WP_048178534.1 | zinc finger AN1 domain-containing stress-associated protein | - |
| MSMTP_RS07820 (MSMTP_1427) | 1839867..1840331 | + | 465 | WP_048178535.1 | hypothetical protein | - |
| MSMTP_RS07825 (MSMTP_1428) | 1840508..1841242 | - | 735 | WP_048178536.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1822306..1851287 | 28981 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 75 a.a. Molecular weight: 8163.76 Da Isoelectric Point: 11.2826
>T49195 WP_048178533.1 NZ_CP009505:1837709-1837933 [Methanosarcina sp. MTP4]
MSGLPVISGMQAIKAFSKAGWFPHRQVGSHVVLRKESSRVTLTVPKHKELKPGLLRKLIKASGLTVEEFEALLK
MSGLPVISGMQAIKAFSKAGWFPHRQVGSHVVLRKESSRVTLTVPKHKELKPGLLRKLIKASGLTVEEFEALLK
Download Length: 225 bp
>T49195 NZ_CP009505:1837709-1837933 [Methanosarcina sp. MTP4]
ATGTCCGGACTTCCTGTAATTTCCGGGATGCAGGCGATTAAAGCCTTTTCTAAAGCTGGCTGGTTCCCGCACCGGCAGGT
GGGCAGCCATGTTGTCCTTCGAAAAGAAAGTTCAAGAGTTACGTTGACTGTTCCGAAGCATAAGGAACTGAAGCCTGGAC
TTTTGAGAAAGTTGATAAAAGCCTCAGGACTTACGGTAGAAGAATTCGAAGCTCTTTTGAAGTAA
ATGTCCGGACTTCCTGTAATTTCCGGGATGCAGGCGATTAAAGCCTTTTCTAAAGCTGGCTGGTTCCCGCACCGGCAGGT
GGGCAGCCATGTTGTCCTTCGAAAAGAAAGTTCAAGAGTTACGTTGACTGTTCCGAAGCATAAGGAACTGAAGCCTGGAC
TTTTGAGAAAGTTGATAAAAGCCTCAGGACTTACGGTAGAAGAATTCGAAGCTCTTTTGAAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 7621.59 Da Isoelectric Point: 3.7933
>AT49195 WP_048178532.1 NZ_CP009505:1837490-1837708 [Methanosarcina sp. MTP4]
MRFKIILEEDEEAGGFVASCPGLPGCFSQGDTAEEAIGNIKEAIQACLESLAEDELQECIGKSSCRVVDVVA
MRFKIILEEDEEAGGFVASCPGLPGCFSQGDTAEEAIGNIKEAIQACLESLAEDELQECIGKSSCRVVDVVA
Download Length: 219 bp
>AT49195 NZ_CP009505:1837490-1837708 [Methanosarcina sp. MTP4]
ATGAGGTTCAAAATTATCCTTGAGGAAGACGAAGAAGCCGGAGGATTTGTTGCCAGCTGCCCCGGCTTACCAGGCTGTTT
TTCGCAGGGGGATACGGCTGAAGAAGCTATCGGAAATATTAAAGAAGCGATTCAGGCCTGTCTGGAATCCCTCGCAGAAG
ATGAACTGCAGGAATGCATAGGGAAATCCTCCTGCAGAGTGGTTGATGTGGTTGCTTGA
ATGAGGTTCAAAATTATCCTTGAGGAAGACGAAGAAGCCGGAGGATTTGTTGCCAGCTGCCCCGGCTTACCAGGCTGTTT
TTCGCAGGGGGATACGGCTGAAGAAGCTATCGGAAATATTAAAGAAGCGATTCAGGCCTGTCTGGAATCCCTCGCAGAAG
ATGAACTGCAGGAATGCATAGGGAAATCCTCCTGCAGAGTGGTTGATGTGGTTGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3NW26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3NWF4 |