49183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1372599..1373242 Replicon chromosome
Accession NZ_CP009495
Organism Mycolicibacterium smegmatis strain INHR1

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4QHE7
Locus tag LI99_RS06335 Protein ID WP_011727564.1
Coordinates 1372853..1373242 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag LI99_RS06330 Protein ID WP_003892665.1
Coordinates 1372599..1372853 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI99_RS06320 1368029..1371412 + 3384 WP_038557635.1 ATP-binding protein -
LI99_RS06325 1371409..1372578 + 1170 WP_011727563.1 DUF3322 and DUF2220 domain-containing protein -
LI99_RS06330 1372599..1372853 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LI99_RS06335 1372853..1373242 + 390 WP_011727564.1 type II toxin-antitoxin system VapC family toxin Toxin
LI99_RS06340 1373261..1375666 - 2406 WP_011727565.1 SEC-C domain-containing protein -
LI99_RS06345 1375688..1377448 - 1761 WP_011727566.1 sulfatase-like hydrolase/transferase -
LI99_RS06350 1377445..1377882 - 438 WP_011727567.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13909.73 Da        Isoelectric Point: 4.7222

>T49183 WP_011727564.1 NZ_CP009495:1372853-1373242 [Mycolicibacterium smegmatis]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEAFRLTDVAAVH

Download         Length: 390 bp

>T49183 NZ_CP009495:1372853-1373242 [Mycolicibacterium smegmatis]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT49183 WP_003892665.1 NZ_CP009495:1372599-1372853 [Mycolicibacterium smegmatis]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT49183 NZ_CP009495:1372599-1372853 [Mycolicibacterium smegmatis]
ATGGCTCTAAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGCCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHE7

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References