Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1372589..1373232 Replicon chromosome
Accession NZ_CP009494
Organism Mycolicibacterium smegmatis MC2 155

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4QHE7
Locus tag LJ00_RS06335 Protein ID WP_011727564.1
Coordinates 1372843..1373232 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag LJ00_RS06330 Protein ID WP_003892665.1
Coordinates 1372589..1372843 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ00_RS06320 1368019..1371402 + 3384 WP_038557635.1 ATP-binding protein -
LJ00_RS06325 1371399..1372568 + 1170 WP_011727563.1 DUF3322 and DUF2220 domain-containing protein -
LJ00_RS06330 1372589..1372843 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJ00_RS06335 1372843..1373232 + 390 WP_011727564.1 type II toxin-antitoxin system VapC family toxin Toxin
LJ00_RS06340 1373251..1375656 - 2406 WP_011727565.1 SEC-C domain-containing protein -
LJ00_RS06345 1375678..1377438 - 1761 WP_011727566.1 sulfatase-like hydrolase/transferase -
LJ00_RS06350 1377435..1377872 - 438 WP_011727567.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13909.73 Da        Isoelectric Point: 4.7222

>T49178 WP_011727564.1 NZ_CP009494:1372843-1373232 [Mycolicibacterium smegmatis MC2 155]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEAFRLTDVAAVH

Download         Length: 390 bp

>T49178 NZ_CP009494:1372843-1373232 [Mycolicibacterium smegmatis MC2 155]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT49178 WP_003892665.1 NZ_CP009494:1372589-1372843 [Mycolicibacterium smegmatis MC2 155]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT49178 NZ_CP009494:1372589-1372843 [Mycolicibacterium smegmatis MC2 155]
ATGGCTCTAAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGCCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHE7

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References