Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 84794..85470 Replicon chromosome
Accession NZ_CP009488
Organism Burkholderia ubonensis MSMB22

Toxin (Protein)


Gene name vagD Uniprot ID A0A853WQ48
Locus tag BW23_RS15380 Protein ID WP_045566124.1
Coordinates 84794..85210 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A118MA44
Locus tag BW23_RS15385 Protein ID WP_010092407.1
Coordinates 85207..85470 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW23_RS15350 80003..80776 + 774 WP_042584010.1 uroporphyrinogen-III C-methyltransferase -
BW23_RS15355 80773..81150 + 378 WP_042584009.1 cobalamin biosynthesis protein -
BW23_RS15360 81179..81781 + 603 WP_010092402.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
BW23_RS15365 81785..83089 + 1305 WP_042584008.1 cobyrinate a,c-diamide synthase -
BW23_RS15370 83183..83428 - 246 WP_045567791.1 type II toxin-antitoxin system ParD family antitoxin -
BW23_RS15375 83497..84660 - 1164 WP_045566123.1 amidohydrolase -
BW23_RS15380 84794..85210 - 417 WP_045566124.1 PIN domain-containing protein Toxin
BW23_RS15385 85207..85470 - 264 WP_010092407.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BW23_RS15390 85683..86705 - 1023 WP_045566125.1 acetyltransferase -
BW23_RS15395 86705..87562 - 858 WP_042584005.1 N(5)-hydroxyornithine transformylase PvdF -
BW23_RS15400 87648..89870 - 2223 WP_045566126.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14560.72 Da        Isoelectric Point: 7.9094

>T49161 WP_045566124.1 NZ_CP009488:c85210-84794 [Burkholderia ubonensis MSMB22]
VTKLYMLDTNICSYIMRERPPVVLSRLQSCVGAQHRIVVSAVTYAEMRFGAIGRKASPKHADLVTAFVARLDGVLPLDAA
AVDATTAVRAELAARGTPIGANDASIAGHAIAAGAVLVTHNTREFGRVGGLSFEDWAD

Download         Length: 417 bp

>T49161 NZ_CP009488:c85210-84794 [Burkholderia ubonensis MSMB22]
GTGACGAAGCTCTACATGCTCGATACGAACATCTGCTCGTACATCATGCGGGAGCGGCCGCCGGTCGTCCTGTCGCGGCT
GCAGTCGTGCGTTGGCGCGCAGCACCGGATCGTCGTGTCGGCCGTGACCTATGCGGAGATGCGCTTCGGCGCGATCGGCC
GGAAGGCGTCGCCGAAGCATGCCGACCTCGTGACCGCATTCGTCGCGCGGCTGGACGGCGTGCTGCCGTTGGATGCGGCG
GCCGTCGACGCGACGACCGCCGTGCGCGCCGAGCTCGCGGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
GGGGCACGCGATCGCGGCCGGCGCGGTGCTGGTGACCCACAACACGCGCGAATTCGGCCGCGTCGGCGGGTTGTCGTTCG
AGGATTGGGCGGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9823.05 Da        Isoelectric Point: 4.6677

>AT49161 WP_010092407.1 NZ_CP009488:c85470-85207 [Burkholderia ubonensis MSMB22]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLVERPAVVESGRFDLSGPDD
AQTESGR

Download         Length: 264 bp

>AT49161 NZ_CP009488:c85470-85207 [Burkholderia ubonensis MSMB22]
ATGCGCACCGTTTCCATTTTCAAGAATGCCCGCAATCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAAGGCGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACCTTGCTGCTTCGCCCCGTGCGTCCCACGTGGACGTCGCTCGCGCACGAGC
CGCTGGCGGATGCCGATTTCCTCGTCGAGCGCCCGGCCGTCGTCGAATCCGGCCGTTTCGACCTGTCCGGCCCCGACGAT
GCGCAAACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853WQ48

Antitoxin

Source ID Structure
AlphaFold DB A0A118MA44

References