Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 242850..243427 Replicon chromosome
Accession NZ_CP009487
Organism Burkholderia ubonensis MSMB22

Toxin (Protein)


Gene name vapC Uniprot ID A0A119F0U2
Locus tag BW23_RS12340 Protein ID WP_042585444.1
Coordinates 242850..243215 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0D0GME8
Locus tag BW23_RS12345 Protein ID WP_042585445.1
Coordinates 243209..243427 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW23_RS12325 238642..238989 - 348 WP_010098558.1 GIY-YIG nuclease family protein -
BW23_RS12330 239048..239749 - 702 WP_042585442.1 autoinducer binding domain-containing protein -
BW23_RS33440 240305..240667 - 363 WP_162487849.1 hypothetical protein -
BW23_RS12335 240685..242853 - 2169 WP_045565601.1 DUF4132 domain-containing protein -
BW23_RS12340 242850..243215 - 366 WP_042585444.1 type II toxin-antitoxin system VapC family toxin Toxin
BW23_RS12345 243209..243427 - 219 WP_042585445.1 ribbon-helix-helix protein, CopG family Antitoxin
BW23_RS12350 243673..244995 - 1323 WP_045565602.1 HipA domain-containing protein -
BW23_RS12355 244992..245561 - 570 WP_045565603.1 helix-turn-helix domain-containing protein -
BW23_RS12360 246413..248008 + 1596 WP_045565604.1 DUF2957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-41)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13319.42 Da        Isoelectric Point: 4.8151

>T49160 WP_042585444.1 NZ_CP009487:c243215-242850 [Burkholderia ubonensis MSMB22]
MVNALFDTNILIDYLNGVEAAKTELARYPAPAISTITWMEVLVGTTPADDAPIRAWLATFEVVDLDSTIADRAVAIRKAR
RIRLPDAIVWASAQVRGLLLVSRNTKDFPAEEPGVRVPYVI

Download         Length: 366 bp

>T49160 NZ_CP009487:c243215-242850 [Burkholderia ubonensis MSMB22]
ATGGTGAACGCCCTGTTCGACACCAATATCCTGATCGACTATCTGAACGGAGTCGAGGCAGCGAAGACAGAACTCGCACG
ATATCCCGCGCCGGCGATCAGCACGATCACCTGGATGGAAGTGCTGGTCGGCACCACGCCTGCCGACGACGCGCCCATCC
GCGCGTGGCTGGCGACGTTCGAAGTGGTCGATCTCGACTCGACTATTGCCGATAGGGCCGTGGCGATCCGCAAAGCGAGG
CGAATTCGTCTACCCGATGCAATCGTCTGGGCGAGCGCGCAGGTCAGGGGGCTGCTGCTGGTCTCGCGCAACACGAAAGA
TTTCCCGGCCGAAGAACCCGGCGTGCGCGTTCCGTACGTCATATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8165.41 Da        Isoelectric Point: 6.3131

>AT49160 WP_042585445.1 NZ_CP009487:c243427-243209 [Burkholderia ubonensis MSMB22]
MSRILVDLPDAQIQALAALVEAERRPRAAVIRDAIDAYLAQRKRAVGADVFGLWKEKKVDGLTYQEALREEW

Download         Length: 219 bp

>AT49160 NZ_CP009487:c243427-243209 [Burkholderia ubonensis MSMB22]
ATGAGCCGAATCCTGGTTGACCTGCCGGACGCACAGATCCAAGCCCTGGCGGCCCTGGTCGAAGCGGAGCGGCGGCCGCG
TGCGGCAGTCATCCGCGACGCGATCGACGCTTACCTCGCACAGCGCAAGCGCGCAGTCGGCGCCGATGTGTTCGGCCTCT
GGAAAGAAAAGAAGGTCGACGGCCTGACGTATCAAGAGGCGTTGCGCGAAGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A119F0U2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0GME8

References