Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2544422..2546172 Replicon chromosome
Accession NZ_CP009486
Organism Burkholderia ubonensis MSMB22

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BW23_RS10855 Protein ID WP_045565160.1
Coordinates 2545270..2546172 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A106IFJ2
Locus tag BW23_RS10850 Protein ID WP_042588189.1
Coordinates 2544422..2545273 (-) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW23_RS10830 2539626..2541116 - 1491 WP_045565157.1 aldehyde dehydrogenase -
BW23_RS10835 2541139..2541972 - 834 WP_045565158.1 aspartate dehydrogenase -
BW23_RS10840 2541965..2543632 - 1668 WP_042588187.1 thiamine pyrophosphate-binding protein -
BW23_RS10845 2543625..2544422 - 798 WP_045565159.1 SDR family oxidoreductase -
BW23_RS10850 2544422..2545273 - 852 WP_042588189.1 IclR family transcriptional regulator Antitoxin
BW23_RS10855 2545270..2546172 - 903 WP_045565160.1 alpha/beta fold hydrolase Toxin
BW23_RS10860 2546191..2546718 - 528 WP_045565495.1 cupin domain-containing protein -
BW23_RS10865 2546745..2547515 - 771 WP_045565161.1 SDR family oxidoreductase -
BW23_RS10870 2547508..2548578 - 1071 WP_045565162.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BW23_RS10875 2548623..2548934 - 312 WP_042588193.1 hypothetical protein -
BW23_RS10880 2548938..2549255 - 318 WP_045565163.1 non-heme iron oxygenase ferredoxin subunit -
BW23_RS10885 2549692..2550771 + 1080 WP_045565164.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-281)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 30923.22 Da        Isoelectric Point: 8.8230

>T49158 WP_045565160.1 NZ_CP009486:c2546172-2545270 [Burkholderia ubonensis MSMB22]
MSVIDKRERDRERIASFAALLERFPEQRSPAGAAGTIGYRAAGAQHAGRTLPVVLLHGIGSGAASWVRQLDALGASRRVF
AWDAPGYGASTPVHGASPAAADYAASLAAWLDALGIDRCVLVGHSLGAIVAGGFARVMPERVAGLLLISPAGGYGSAPAE
TRASRRDARLAMLAELGPAGLAAQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVA
VGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYTALIETFCRQCDLQRGLA

Download         Length: 903 bp

>T49158 NZ_CP009486:c2546172-2545270 [Burkholderia ubonensis MSMB22]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCGAGCGCATCGCGAGCTTCGCAGCGCTGCTCGAGCGGTTTCCCGAGCA
GCGCTCGCCGGCCGGCGCGGCGGGCACGATCGGCTACCGCGCGGCCGGCGCGCAGCATGCGGGCCGCACGCTCCCCGTCG
TGCTGCTGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGATGCGCTCGGCGCTTCGCGGCGCGTGTTC
GCATGGGATGCGCCCGGCTACGGCGCGTCGACGCCGGTGCACGGCGCATCGCCGGCCGCAGCCGACTACGCGGCATCGCT
CGCCGCGTGGCTCGATGCGCTCGGCATCGACCGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCGTCGCGGGCGGCT
TCGCCCGCGTGATGCCGGAGCGCGTCGCCGGGCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCGGCCGAG
ACGCGCGCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGCGCAGCGCAGCGG
CAACATGCTGTCCGGCTTTGCGAGCGAGGACGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCT
ACGCACAGGCGACGCACCTGCTCGCGAACGCCGATCTCGCGTCGGACCTCGCGGGCTTTCGCGGCCGCACGGCGGTGGCC
GTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGGCGGCCGCGCATGTCGGGCTGCAGGTGAT
TCCGCAGGCCGGACATGCGGGCTACGTCGAGGCGCCGGCTGTCTATACGGCACTGATCGAAACGTTCTGCCGTCAGTGCG
ACCTGCAGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 31105.59 Da        Isoelectric Point: 6.3578

>AT49158 WP_042588189.1 NZ_CP009486:c2545273-2544422 [Burkholderia ubonensis MSMB22]
MSEPLLNENDGAKGEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLGELRALYPERTLNRMTNATPDTVDALYEMIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGL

Download         Length: 852 bp

>AT49158 NZ_CP009486:c2545273-2544422 [Burkholderia ubonensis MSMB22]
ATGAGCGAACCGCTGCTGAATGAAAACGACGGCGCGAAGGGCGAAGCGAACTACGTGGTGCCGGGCCTCGAACGGGGCTT
GAGGATCCTCGCGGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTAGGTTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTTGGCCTGCCCGTGATCGAAAG
CCTGCGCGACGCGACCGGGTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGCCGGTGTTCAGCTCGATCCGGGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACCACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGGGCGAGCTGCGCGCGCTGTATCCGGAACGCACGCTGAACCGGATGACGAACGCGACGCC
GGACACGGTCGATGCGTTGTACGAAATGATCCGCGAGGATGCGTTGCGCGGCTACGGCGTCAGCAACTCGTCGTTCGAGC
GCGGCATCTCGGTCGTCACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAACTACCGCTCGGACGACGAGCACACGTTTCTGAAGGCTTTGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A106IFJ2

References