Detailed information of TA system TA049155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 99373..100609
• Replicon: chromosome
• Accession: NZ_CP009486
• Organism: Burkholderia ubonensis MSMB22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BW23_RS00475
• Protein ID: WP_045563789.1
• Coordinates: 100028..100609 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BW23_RS00470
• Protein ID: WP_045563788.1
• Coordinates: 99373..99930 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BW23_RS00445	94565..95503	-	939	WP_045563783.1	S1C family serine protease	-
BW23_RS00450	95802..96701	+	900	WP_045563784.1	LysR family transcriptional regulator	-
BW23_RS00455	96825..97457	+	633	WP_045563785.1	LysE family translocator	-
BW23_RS00460	97638..98054	-	417	WP_045563786.1	hypothetical protein	-
BW23_RS00465	98398..99129	-	732	WP_045563787.1	ribonuclease T2	-
BW23_RS00470	99373..99930	+	558	WP_045563788.1	helix-turn-helix domain-containing protein	Antitoxin
BW23_RS00475	100028..100609	+	582	WP_045563789.1	HD domain-containing protein	Toxin
BW23_RS00480	100764..101954	+	1191	WP_045563790.1	macrolide transporter subunit MacA	-
BW23_RS00485	101957..103996	+	2040	WP_045563791.1	MacB family efflux pump subunit	-
BW23_RS00490	104002..105396	+	1395	WP_045563792.1	efflux transporter outer membrane subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-183)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-61)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21202.86 Da
• Isoelectric Point: 5.7890

>T49155 WP_045563789.1 NZ_CP009486:100028-100609 [Burkholderia ubonensis MSMB22]
MTPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLTLTAGLDAAPRDEIVALWDEYEQAASPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTNASPLFRAIRAIVDADTQSRIDAGARRA

Nucleotide

• Length: 582 bp

>T49155 NZ_CP009486:100028-100609 [Burkholderia ubonensis MSMB22]
ATGACTCCCGACACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCATCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTGACGCTGACCGCCGGCCTCGACGC
CGCGCCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGCAGGCCGCGTCGCCGGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCGACAATCCGCCGGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCCATACGAACGCGAGCCCGCTGTTCCGCGCGATCCGGGCGATCGTCGACGCCGACACGCAAAGCCGGATCGA
CGCCGGCGCGCGGCGCGCGTGA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20199.29 Da
• Isoelectric Point: 10.5411

>AT49155 WP_045563788.1 NZ_CP009486:99373-99930 [Burkholderia ubonensis MSMB22]
MTDSPLQTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLVGD
HPGRVHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPSVEFASGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT49155 NZ_CP009486:99373-99930 [Burkholderia ubonensis MSMB22]
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGCTGCTGAAGCGCTGGCGGCTGCTGCGCCGCGTCAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAGTCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGACCGCGCGCTCGCGCGGCTCGTCGGCGAC
CATCCCGGCCGCGTGCACCTCGTGTGCGACCTCACGCATCGGCTGCTGGCGTGCTCGTCGCTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAAGCGTCGCTCG
ACACGCTCGGCTGGCGCGACAGCGCCGGGCCGCCGAGCGTCGAGTTCGCCAGCGGCGCGAACGCATCGCGCATCGTGCCG
ATCCGTCGCAGCACCTGCCGCTGGACGCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTAG