Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 631982..632637 Replicon chromosome
Accession NZ_CP009478
Organism Burkholderia pseudomallei MSHR2543

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BG16_RS15810 Protein ID WP_006027262.1
Coordinates 632341..632637 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BG16_RS15805 Protein ID WP_004202809.1
Coordinates 631982..632338 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG16_RS15785 627117..628130 - 1014 WP_004531048.1 phage major capsid protein, P2 family -
BG16_RS15790 628164..628973 - 810 WP_004552664.1 GPO family capsid scaffolding protein -
BG16_RS15795 629117..630886 + 1770 WP_045588385.1 terminase ATPase subunit family protein -
BG16_RS15800 630883..631938 + 1056 WP_038726677.1 phage portal protein -
BG16_RS15805 631982..632338 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BG16_RS15810 632341..632637 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG16_RS40730 633374..633991 + 618 WP_144411744.1 hypothetical protein -
BG16_RS36890 634224..634352 - 129 WP_038781962.1 ribbon-helix-helix protein, CopG family -
BG16_RS15820 634577..635233 - 657 WP_038781956.1 AAA family ATPase -
BG16_RS15825 635323..635529 - 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
BG16_RS15830 635526..635792 - 267 WP_038789831.1 ogr/Delta-like zinc finger family protein -
BG16_RS15835 635808..637601 - 1794 WP_041188822.1 replication endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 602635..646902 44267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T49149 WP_006027262.1 NZ_CP009478:c632637-632341 [Burkholderia pseudomallei MSHR2543]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49149 NZ_CP009478:c632637-632341 [Burkholderia pseudomallei MSHR2543]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49149 WP_004202809.1 NZ_CP009478:c632338-631982 [Burkholderia pseudomallei MSHR2543]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49149 NZ_CP009478:c632338-631982 [Burkholderia pseudomallei MSHR2543]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References