Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2518310..2518952 Replicon chromosome
Accession NZ_CP009476
Organism Bacillus anthracis strain Pasteur

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag BF26_RS13840 Protein ID WP_000635963.1
Coordinates 2518310..2518660 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BF26_RS13845 Protein ID WP_000004570.1
Coordinates 2518665..2518952 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF26_RS13825 2515246..2515704 - 459 WP_000344248.1 SprT family protein -
BF26_RS13830 2515900..2516016 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
BF26_RS13835 2516074..2518242 - 2169 WP_000426225.1 RNA-binding transcriptional accessory protein -
BF26_RS13840 2518310..2518660 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BF26_RS13845 2518665..2518952 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
BF26_RS13850 2519262..2520431 - 1170 WP_000390596.1 alanine racemase -
BF26_RS13855 2520550..2521500 - 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
BF26_RS13860 2521657..2522016 - 360 WP_000635040.1 holo-ACP synthase -
BF26_RS13865 2522109..2522681 + 573 WP_000906916.1 rhomboid family intramembrane serine protease -
BF26_RS13870 2522674..2523636 - 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T49144 WP_000635963.1 NZ_CP009476:c2518660-2518310 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T49144 NZ_CP009476:c2518660-2518310 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT49144 WP_000004570.1 NZ_CP009476:c2518952-2518665 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT49144 NZ_CP009476:c2518952-2518665 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References