Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 472302..473277 Replicon chromosome
Accession NZ_CP009476
Organism Bacillus anthracis strain Pasteur

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BF26_RS03010 Protein ID WP_002036394.1
Coordinates 472540..473277 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BF26_RS03005 Protein ID WP_000588712.1
Coordinates 472302..472427 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF26_RS02975 468056..468526 + 471 WP_000670597.1 DUF5065 family protein -
BF26_RS02980 469090..470559 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BF26_RS30795 470703..470879 - 177 WP_000808045.1 hypothetical protein -
BF26_RS02990 471218..471454 + 237 WP_001021689.1 hypothetical protein -
BF26_RS02995 471731..472012 + 282 WP_001041555.1 hypothetical protein -
BF26_RS30800 472049..472225 - 177 WP_000852614.1 hypothetical protein -
BF26_RS03005 472302..472427 - 126 WP_000588712.1 hypothetical protein Antitoxin
BF26_RS03010 472540..473277 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF26_RS03015 473466..474203 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF26_RS03020 474371..474853 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BF26_RS03025 474960..476645 + 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
BF26_RS03030 476767..477549 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T49143 WP_002036394.1 NZ_CP009476:c473277-472540 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T49143 NZ_CP009476:c473277-472540 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT49143 WP_000588712.1 NZ_CP009476:c472427-472302 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT49143 NZ_CP009476:c472427-472302 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References