49142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2538621..2539276 Replicon chromosome
Accession NZ_CP009473
Organism Burkholderia pseudomallei MSHR840

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BG19_RS10405 Protein ID WP_006027262.1
Coordinates 2538621..2538917 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BG19_RS10410 Protein ID WP_004202809.1
Coordinates 2538920..2539276 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG19_RS10395 2533626..2534990 + 1365 WP_051781513.1 GGDEF domain-containing protein -
BG19_RS10400 2535101..2537350 + 2250 WP_045604247.1 glycosyltransferase -
BG19_RS33645 2537277..2537990 + 714 WP_080002914.1 cellulose biosynthesis protein BcsS -
BG19_RS10405 2538621..2538917 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG19_RS10410 2538920..2539276 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BG19_RS10415 2539320..2540375 - 1056 WP_038738790.1 phage portal protein -
BG19_RS10420 2540372..2542141 - 1770 WP_045604249.1 terminase ATPase subunit family protein -
BG19_RS10425 2542285..2543094 + 810 WP_004552664.1 GPO family capsid scaffolding protein -
BG19_RS10430 2543128..2544141 + 1014 WP_045604250.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2523681..2563113 39432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T49142 WP_006027262.1 NZ_CP009473:2538621-2538917 [Burkholderia pseudomallei MSHR840]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49142 NZ_CP009473:2538621-2538917 [Burkholderia pseudomallei MSHR840]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGTGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49142 WP_004202809.1 NZ_CP009473:2538920-2539276 [Burkholderia pseudomallei MSHR840]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49142 NZ_CP009473:2538920-2539276 [Burkholderia pseudomallei MSHR840]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References