Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 2391192..2391751 | Replicon | chromosome |
| Accession | NZ_CP009467 | ||
| Organism | Vibrio harveyi strain ATCC 33843 (392 [MAV]) | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR22 |
| Locus tag | LA59_RS10985 | Protein ID | WP_005398411.1 |
| Coordinates | 2391473..2391751 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LA59_RS10980 | Protein ID | WP_069687317.1 |
| Coordinates | 2391192..2391476 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA59_RS27225 | 2386434..2386526 | - | 93 | WP_079767291.1 | DUF3265 domain-containing protein | - |
| LA59_RS10955 | 2386541..2387014 | - | 474 | WP_069687314.1 | GrpB family protein | - |
| LA59_RS27230 | 2387043..2387135 | - | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| LA59_RS10960 | 2387161..2387865 | - | 705 | WP_045459146.1 | HNH endonuclease | - |
| LA59_RS27235 | 2387903..2387995 | - | 93 | WP_017821981.1 | DUF3265 domain-containing protein | - |
| LA59_RS27240 | 2388450..2388542 | - | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| LA59_RS28050 | 2388568..2388993 | - | 426 | WP_145924710.1 | HNH endonuclease | - |
| LA59_RS27245 | 2389432..2389569 | - | 138 | WP_081334164.1 | DUF3265 domain-containing protein | - |
| LA59_RS10970 | 2389547..2389927 | - | 381 | WP_069687316.1 | DUF4087 domain-containing protein | - |
| LA59_RS27250 | 2389955..2390047 | - | 93 | WP_081334139.1 | DUF3265 domain-containing protein | - |
| LA59_RS10975 | 2390062..2390997 | - | 936 | WP_025628297.1 | nucleoside 2-deoxyribosyltransferase | - |
| LA59_RS27255 | 2390990..2391115 | - | 126 | WP_145924692.1 | DUF3265 domain-containing protein | - |
| LA59_RS10980 | 2391192..2391476 | + | 285 | WP_069687317.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LA59_RS10985 | 2391473..2391751 | + | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| LA59_RS27260 | 2391780..2391872 | - | 93 | WP_005445238.1 | DUF3265 domain-containing protein | - |
| LA59_RS27275 | 2392399..2392491 | - | 93 | WP_081334141.1 | DUF3265 domain-containing protein | - |
| LA59_RS10990 | 2392506..2393591 | - | 1086 | WP_069687318.1 | pentapeptide repeat-containing protein | - |
| LA59_RS27280 | 2393687..2393818 | - | 132 | WP_074191342.1 | DUF3265 domain-containing protein | - |
| LA59_RS27285 | 2394306..2394398 | - | 93 | WP_004748931.1 | DUF3265 domain-containing protein | - |
| LA59_RS10995 | 2394413..2395123 | - | 711 | WP_052447908.1 | hypothetical protein | - |
| LA59_RS27290 | 2395151..2395243 | - | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| LA59_RS11000 | 2395258..2396034 | - | 777 | WP_069687319.1 | DUF4393 domain-containing protein | - |
| LA59_RS28450 | 2396067..2396159 | - | 93 | WP_201258212.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2303852..2400792 | 96940 | |
| - | inside | Integron | - | - | 2307992..2400792 | 92800 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10891.57 Da Isoelectric Point: 4.3430
>T49138 WP_005398411.1 NZ_CP009467:2391473-2391751 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T49138 NZ_CP009467:2391473-2391751 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTATTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTATTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11016.35 Da Isoelectric Point: 7.8664
>AT49138 WP_069687317.1 NZ_CP009467:2391192-2391476 [Vibrio harveyi]
MDTRIQFRVDEETKCLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKCLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT49138 NZ_CP009467:2391192-2391476 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAATGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAATGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|