Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2385379..2385938 Replicon chromosome
Accession NZ_CP009467
Organism Vibrio harveyi strain ATCC 33843 (392 [MAV])

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LA59_RS10950 Protein ID WP_069687313.1
Coordinates 2385660..2385938 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LA59_RS10945 Protein ID WP_069687312.1
Coordinates 2385379..2385663 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA59_RS27205 2381225..2381347 - 123 WP_201258226.1 DUF3265 domain-containing protein -
LA59_RS10910 2381343..2381801 - 459 WP_069687307.1 GNAT family N-acetyltransferase -
LA59_RS27210 2381833..2381925 - 93 WP_017790380.1 DUF3265 domain-containing protein -
LA59_RS28335 2381948..2382121 - 174 WP_158515399.1 hypothetical protein -
LA59_RS10920 2382123..2382722 - 600 WP_069687309.1 hypothetical protein -
LA59_RS10925 2382915..2383424 - 510 WP_069687310.1 ClbS/DfsB family four-helix bundle protein -
LA59_RS27215 2383452..2383544 - 93 WP_201258211.1 DUF3265 domain-containing protein -
LA59_RS10930 2383559..2383930 - 372 WP_069687572.1 hypothetical protein -
LA59_RS10935 2384085..2384447 - 363 WP_050937243.1 hypothetical protein -
LA59_RS10940 2384656..2385165 + 510 WP_069687311.1 MerR family transcriptional regulator -
LA59_RS10945 2385379..2385663 + 285 WP_069687312.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LA59_RS10950 2385660..2385938 + 279 WP_069687313.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LA59_RS27220 2385967..2386092 - 126 WP_072036428.1 DUF3265 domain-containing protein -
LA59_RS27225 2386434..2386526 - 93 WP_079767291.1 DUF3265 domain-containing protein -
LA59_RS10955 2386541..2387014 - 474 WP_069687314.1 GrpB family protein -
LA59_RS27230 2387043..2387135 - 93 WP_072612521.1 DUF3265 domain-containing protein -
LA59_RS10960 2387161..2387865 - 705 WP_045459146.1 HNH endonuclease -
LA59_RS27235 2387903..2387995 - 93 WP_017821981.1 DUF3265 domain-containing protein -
LA59_RS27240 2388450..2388542 - 93 WP_072612521.1 DUF3265 domain-containing protein -
LA59_RS28050 2388568..2388993 - 426 WP_145924710.1 HNH endonuclease -
LA59_RS27245 2389432..2389569 - 138 WP_081334164.1 DUF3265 domain-containing protein -
LA59_RS10970 2389547..2389927 - 381 WP_069687316.1 DUF4087 domain-containing protein -
LA59_RS27250 2389955..2390047 - 93 WP_081334139.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2303852..2400792 96940
- inside Integron - - 2307992..2400792 92800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3324

>T49137 WP_069687313.1 NZ_CP009467:2385660-2385938 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T49137 NZ_CP009467:2385660-2385938 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGACTACTCATTATCCCTGACATTTCGATGATTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11067.43 Da        Isoelectric Point: 9.2167

>AT49137 WP_069687312.1 NZ_CP009467:2385379-2385663 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDVWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT49137 NZ_CP009467:2385379-2385663 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAGCATTGTCTCACGATGTATGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References