Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 2372966..2373515 | Replicon | chromosome |
| Accession | NZ_CP009467 | ||
| Organism | Vibrio harveyi strain ATCC 33843 (392 [MAV]) | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A2K7SRW8 |
| Locus tag | LA59_RS10860 | Protein ID | WP_015296889.1 |
| Coordinates | 2373216..2373515 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A347UQT2 |
| Locus tag | LA59_RS10855 | Protein ID | WP_005442033.1 |
| Coordinates | 2372966..2373208 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA59_RS10825 | 2367978..2368352 | - | 375 | WP_069687300.1 | hypothetical protein | - |
| LA59_RS27135 | 2368416..2368508 | - | 93 | WP_201258209.1 | DUF3265 domain-containing protein | - |
| LA59_RS27140 | 2368534..2369091 | - | 558 | WP_081334130.1 | helix-turn-helix domain-containing protein | - |
| LA59_RS27145 | 2369119..2369211 | - | 93 | WP_004418565.1 | DUF3265 domain-containing protein | - |
| LA59_RS10835 | 2369233..2369820 | - | 588 | WP_069687301.1 | DUF1311 domain-containing protein | - |
| LA59_RS10840 | 2369934..2370608 | - | 675 | WP_069687302.1 | hypothetical protein | - |
| LA59_RS27150 | 2370637..2370729 | - | 93 | WP_080342040.1 | DUF3265 domain-containing protein | - |
| LA59_RS28330 | 2370749..2371339 | - | 591 | WP_050933505.1 | hypothetical protein | - |
| LA59_RS10850 | 2371471..2372691 | - | 1221 | WP_069687303.1 | hypothetical protein | - |
| LA59_RS27165 | 2372763..2372891 | - | 129 | WP_081334156.1 | DUF3265 domain-containing protein | - |
| LA59_RS10855 | 2372966..2373208 | + | 243 | WP_005442033.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LA59_RS10860 | 2373216..2373515 | + | 300 | WP_015296889.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LA59_RS27170 | 2374110..2374241 | - | 132 | WP_074050600.1 | DUF3265 domain-containing protein | - |
| LA59_RS28445 | 2374729..2374821 | - | 93 | WP_079740779.1 | DUF3265 domain-containing protein | - |
| LA59_RS10870 | 2374913..2375185 | - | 273 | WP_045132854.1 | hypothetical protein | - |
| LA59_RS10875 | 2375339..2376307 | - | 969 | WP_047482961.1 | DUF2971 domain-containing protein | - |
| LA59_RS10880 | 2376459..2377361 | - | 903 | WP_069687304.1 | hypothetical protein | - |
| LA59_RS27190 | 2377388..2377477 | - | 90 | WP_071881309.1 | DUF3265 domain-containing protein | - |
| LA59_RS10885 | 2377515..2377757 | - | 243 | WP_198556839.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2303852..2400792 | 96940 | |
| - | inside | Integron | - | - | 2307992..2400792 | 92800 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11502.11 Da Isoelectric Point: 9.3224
>T49136 WP_015296889.1 NZ_CP009467:2373216-2373515 [Vibrio harveyi]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK
Download Length: 300 bp
>T49136 NZ_CP009467:2373216-2373515 [Vibrio harveyi]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCACAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCACAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9047.26 Da Isoelectric Point: 5.6926
>AT49136 WP_005442033.1 NZ_CP009467:2372966-2373208 [Vibrio harveyi]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL
Download Length: 243 bp
>AT49136 NZ_CP009467:2372966-2373208 [Vibrio harveyi]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K7SRW8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UQT2 |