Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 2334962..2335509 | Replicon | chromosome |
| Accession | NZ_CP009467 | ||
| Organism | Vibrio harveyi strain ATCC 33843 (392 [MAV]) | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR19 |
| Locus tag | LA59_RS10620 | Protein ID | WP_025548916.1 |
| Coordinates | 2334962..2335264 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LA59_RS10625 | Protein ID | WP_069687268.1 |
| Coordinates | 2335252..2335509 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA59_RS10595 | 2330509..2331435 | - | 927 | WP_069687264.1 | DUF4365 domain-containing protein | - |
| LA59_RS28365 | 2331578..2331955 | - | 378 | WP_069687265.1 | hypothetical protein | - |
| LA59_RS26965 | 2332013..2332141 | - | 129 | WP_072609596.1 | DUF3265 domain-containing protein | - |
| LA59_RS10605 | 2332129..2332644 | - | 516 | WP_069687266.1 | GNAT family N-acetyltransferase | - |
| LA59_RS26970 | 2333220..2333312 | - | 93 | WP_201258204.1 | DUF3265 domain-containing protein | - |
| LA59_RS10610 | 2333337..2334329 | - | 993 | WP_069687267.1 | hypothetical protein | - |
| LA59_RS26975 | 2334358..2334447 | - | 90 | WP_072039143.1 | DUF3265 domain-containing protein | - |
| LA59_RS10615 | 2334465..2334743 | - | 279 | WP_033007115.1 | hypothetical protein | - |
| LA59_RS26980 | 2334834..2334926 | - | 93 | WP_081334116.1 | DUF3265 domain-containing protein | - |
| LA59_RS10620 | 2334962..2335264 | - | 303 | WP_025548916.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LA59_RS10625 | 2335252..2335509 | - | 258 | WP_069687268.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LA59_RS26985 | 2335591..2335713 | - | 123 | WP_081334117.1 | DUF3265 domain-containing protein | - |
| LA59_RS10630 | 2335698..2336174 | - | 477 | WP_069687269.1 | GNAT family N-acetyltransferase | - |
| LA59_RS26990 | 2336208..2336300 | - | 93 | WP_104027199.1 | DUF3265 domain-containing protein | - |
| LA59_RS10635 | 2336326..2336742 | - | 417 | WP_069687270.1 | GNAT family N-acetyltransferase | - |
| LA59_RS26995 | 2336787..2336879 | - | 93 | WP_196298318.1 | DUF3265 domain-containing protein | - |
| LA59_RS10640 | 2336924..2337868 | - | 945 | WP_069687271.1 | D-2-hydroxyacid dehydrogenase family protein | - |
| LA59_RS10650 | 2338505..2338819 | - | 315 | WP_069687273.1 | hypothetical protein | - |
| LA59_RS27000 | 2338939..2339028 | - | 90 | WP_097372136.1 | DUF3265 domain-containing protein | - |
| LA59_RS10655 | 2339055..2339825 | - | 771 | WP_069687274.1 | hypothetical protein | - |
| LA59_RS28425 | 2339872..2339964 | - | 93 | WP_201258223.1 | DUF3265 domain-containing protein | - |
| LA59_RS27015 | 2340361..2340483 | - | 123 | WP_080772466.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2303852..2400792 | 96940 | |
| - | inside | Integron | - | - | 2307992..2400792 | 92800 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11669.57 Da Isoelectric Point: 5.1765
>T49135 WP_025548916.1 NZ_CP009467:c2335264-2334962 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T49135 NZ_CP009467:c2335264-2334962 [Vibrio harveyi]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCAGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTTGAACGCCTACAAACTTTCCCTGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAG
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCAGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTTGAACGCCTACAAACTTTCCCTGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9592.07 Da Isoelectric Point: 6.7269
>AT49135 WP_069687268.1 NZ_CP009467:c2335509-2335252 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKLASHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKLASHDEAKDKM
SKWLK
Download Length: 258 bp
>AT49135 NZ_CP009467:c2335509-2335252 [Vibrio harveyi]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGGATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAATTGGCAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGGATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAATTGGCAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|