Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2315921..2316470 Replicon chromosome
Accession NZ_CP009467
Organism Vibrio harveyi strain ATCC 33843 (392 [MAV])

Toxin (Protein)


Gene name parE Uniprot ID A0A2K7SRW8
Locus tag LA59_RS10515 Protein ID WP_015296889.1
Coordinates 2316171..2316470 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag LA59_RS10510 Protein ID WP_005442033.1
Coordinates 2315921..2316163 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA59_RS28320 2311361..2311516 - 156 WP_158515397.1 hypothetical protein -
LA59_RS10470 2311735..2311992 - 258 Protein_1999 BrnT family toxin -
LA59_RS10480 2312601..2312795 - 195 WP_069687250.1 hypothetical protein -
LA59_RS26870 2312834..2312926 - 93 WP_201258221.1 DUF3265 domain-containing protein -
LA59_RS10485 2313251..2313673 - 423 WP_069687251.1 hypothetical protein -
LA59_RS26875 2314037..2314128 - 92 Protein_2003 DUF3265 domain-containing protein -
LA59_RS10495 2314163..2314471 - 309 WP_069687253.1 hypothetical protein -
LA59_RS26880 2314500..2314622 - 123 WP_081334108.1 DUF3265 domain-containing protein -
LA59_RS10500 2314607..2315083 - 477 WP_005500215.1 GNAT family N-acetyltransferase -
LA59_RS26885 2315098..2315205 - 108 WP_081334155.1 DUF3265 domain-containing protein -
LA59_RS10505 2315223..2315672 - 450 WP_005448614.1 hypothetical protein -
LA59_RS26890 2315718..2315846 - 129 WP_081334156.1 DUF3265 domain-containing protein -
LA59_RS10510 2315921..2316163 + 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LA59_RS10515 2316171..2316470 + 300 WP_015296889.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA59_RS28420 2316534..2316626 - 93 WP_078555087.1 DUF3265 domain-containing protein -
LA59_RS10520 2316652..2317239 - 588 WP_069687254.1 hypothetical protein -
LA59_RS10525 2317383..2317841 - 459 WP_145924684.1 hypothetical protein -
LA59_RS26900 2317916..2318038 - 123 WP_081334110.1 DUF3265 domain-containing protein -
LA59_RS10530 2318035..2318334 - 300 WP_069687256.1 hypothetical protein -
LA59_RS26905 2318364..2318489 - 126 WP_081334157.1 DUF3265 domain-containing protein -
LA59_RS10535 2318938..2319564 - 627 WP_069687257.1 hypothetical protein -
LA59_RS26910 2319593..2319703 - 111 WP_081334158.1 DUF3265 domain-containing protein -
LA59_RS10540 2319700..2320230 - 531 WP_069687258.1 hypothetical protein -
LA59_RS26915 2320259..2320351 - 93 WP_131170466.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2303852..2400792 96940
- inside Integron - - 2307992..2400792 92800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11502.11 Da        Isoelectric Point: 9.3224

>T49134 WP_015296889.1 NZ_CP009467:2316171-2316470 [Vibrio harveyi]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T49134 NZ_CP009467:2316171-2316470 [Vibrio harveyi]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCACAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT49134 WP_005442033.1 NZ_CP009467:2315921-2316163 [Vibrio harveyi]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT49134 NZ_CP009467:2315921-2316163 [Vibrio harveyi]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2K7SRW8


Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References