Detailed information of TA system TA049133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 4008312..4009287
• Replicon: chromosome
• Accession: NZ_CP009464
• Organism: Bacillus anthracis strain SK-102

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A2R2IKP2
• Locus tag: BF31_RS22780
• Protein ID: WP_002036394.1
• Coordinates: 4008550..4009287 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: BF31_RS22775
• Protein ID: WP_000588712.1
• Coordinates: 4008312..4008437 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BF31_RS22745	4004066..4004536	+	471	WP_000670597.1	DUF5065 family protein	-
BF31_RS22750	4005100..4006569	-	1470	WP_000287522.1	beta-Ala-His dipeptidase	-
BF31_RS32245	4006713..4006889	-	177	WP_000808045.1	hypothetical protein	-
BF31_RS22760	4007228..4007464	+	237	WP_001021689.1	hypothetical protein	-
BF31_RS22765	4007741..4008022	+	282	WP_001041555.1	hypothetical protein	-
BF31_RS32250	4008059..4008235	-	177	WP_000852614.1	hypothetical protein	-
BF31_RS22775	4008312..4008437	-	126	WP_000588712.1	hypothetical protein	Antitoxin
BF31_RS22780	4008550..4009287	-	738	WP_002036394.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BF31_RS22785	4009476..4010213	-	738	WP_000594139.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BF31_RS22790	4010381..4010863	-	483	WP_000191911.1	MarR family winged helix-turn-helix transcriptional regulator	-
BF31_RS22795	4010970..4012655	+	1686	WP_014654562.1	alpha-keto acid decarboxylase family protein	-
BF31_RS22800	4012777..4013559	-	783	WP_000381787.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28373.03 Da
• Isoelectric Point: 8.2705

>T49133 WP_002036394.1 NZ_CP009464:c4009287-4008550 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T49133 NZ_CP009464:c4009287-4008550 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT49133 WP_000588712.1 NZ_CP009464:c4008437-4008312 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT49133 NZ_CP009464:c4008437-4008312 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A2R2IKP2

Antitoxin

• AlphaFold DB: A0A366GQT1