Detailed information of TA system TA049115

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 943901..944559
• Replicon: chromosome
• Accession: NZ_CP009461
• Organism: Klebsiella pneumoniae strain XH209

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: LQ47_RS04775
• Protein ID: WP_038434453.1
• Coordinates: 943901..944221 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: LQ47_RS04780
• Protein ID: WP_038434454.1
• Coordinates: 944242..944559 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ47_RS25595	940296..941261	-	966	WP_023301570.1	retron St85 family RNA-directed DNA polymerase	-
LQ47_RS04765	941687..942328	-	642	WP_023301571.1	hypothetical protein	-
LQ47_RS28185	942330..942746	-	417	WP_072145337.1	preprotein translocase	-
LQ47_RS28190	943010..943576	-	567	Protein_920	integrase arm-type DNA-binding domain-containing protein	-
LQ47_RS04775	943901..944221	-	321	WP_038434453.1	TA system toxin CbtA family protein	Toxin
LQ47_RS04780	944242..944559	-	318	WP_038434454.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LQ47_RS04785	944577..944798	-	222	WP_038434455.1	DUF987 domain-containing protein	-
LQ47_RS04790	944807..945289	-	483	WP_038434456.1	DNA repair protein RadC	-
LQ47_RS04795	945298..945756	-	459	WP_038434458.1	antirestriction protein	-
LQ47_RS04800	945842..946078	-	237	WP_038434459.1	DUF905 domain-containing protein	-
LQ47_RS04805	946156..946566	-	411	WP_038434460.1	hypothetical protein	-
LQ47_RS04810	946633..947070	-	438	WP_038434461.1	hypothetical protein	-
LQ47_RS04815	947112..947648	-	537	WP_038434462.1	DUF4339 domain-containing protein	-
LQ47_RS04820	947674..948384	-	711	WP_038434463.1	DeoR family transcriptional regulator	-
LQ47_RS04825	948593..949417	-	825	WP_038434464.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	929412..967004	37592

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-102)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12113.24 Da
• Isoelectric Point: 9.7207

>T49115 WP_038434453.1 NZ_CP009461:c944221-943901 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLRQHYGLTLNDTPFSNETVIKEHIDAGISLVDAVNFLVEKYELVRIDSKGF
SWQEQSPFITAVDILKARRAMREMRI

Nucleotide

• Length: 321 bp

>T49115 NZ_CP009461:c944221-943901 [Klebsiella pneumoniae]
ATGAAAACCCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCAGTAGCTGTCTGGCAAATGTTACTGAC
ACGCCTGCTTAGACAGCACTATGGCCTGACACTGAACGACACGCCGTTCAGTAATGAAACTGTTATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGTCGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATAGATAGTAAGGGGTTT
AGCTGGCAAGAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAATTTA
A

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11761.34 Da
• Isoelectric Point: 6.9362

>AT49115 WP_038434454.1 NZ_CP009461:c944559-944242 [Klebsiella pneumoniae]
MSNTTWGLQRDITPCLGARLVQEGNRLHYLDDRASITGKFSDAQCIKLNVVFPHFISQIESVLTTGELNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT49115 NZ_CP009461:c944559-944242 [Klebsiella pneumoniae]
ATGAGCAACACCACATGGGGCCTGCAGAGGGATATCACGCCGTGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGATGACCGGGCCAGTATCACCGGTAAGTTTAGTGATGCCCAATGTATTAAGCTGAATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGGTGCTGACCACTGGCGAACTGAATCCCCGTCATGCCCACTGCGTTACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAGCGCTAA