Detailed information of TA system TA049110

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2060639..2061317
• Replicon: chromosome
• Accession: NZ_CP009460
• Organism: Dickeya fangzhongdai strain ND14b

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LH89_RS08685
• Protein ID: WP_023637601.1
• Coordinates: 2060639..2061070 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2K8QSU7
• Locus tag: LH89_RS08690
• Protein ID: WP_023637600.1
• Coordinates: 2061051..2061317 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH89_RS08665	2056599..2057315	-	717	WP_038662295.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LH89_RS08670	2057405..2058304	-	900	WP_038662300.1	site-specific tyrosine recombinase XerD	-
LH89_RS08675	2058567..2059892	+	1326	WP_038662304.1	MHS family MFS transporter	-
LH89_RS08680	2060021..2060539	+	519	WP_038662307.1	flavodoxin FldB	-
LH89_RS08685	2060639..2061070	-	432	WP_023637601.1	protein YgfX	Toxin
LH89_RS08690	2061051..2061317	-	267	WP_023637600.1	FAD assembly factor SdhE	Antitoxin
LH89_RS08695	2061628..2062608	+	981	WP_038662316.1	tRNA-modifying protein YgfZ	-
LH89_RS08700	2062682..2063332	-	651	WP_038662319.1	hemolysin III family protein	-
LH89_RS08705	2063543..2064151	+	609	WP_038662323.1	HD domain-containing protein	-
LH89_RS08710	2064222..2064872	-	651	WP_038662326.1	LysE family translocator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16808.51 Da
• Isoelectric Point: 11.7737

>T49110 WP_023637601.1 NZ_CP009460:c2061070-2060639 [Dickeya fangzhongdai]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T49110 NZ_CP009460:c2061070-2060639 [Dickeya fangzhongdai]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGTTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTATGGTTGGGGCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACTGGCAAAGGGCA
TCAGCGCCTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAATGGCGGCTGTTGCGCCAGCTGTTGCAGCAGCACCCGC
TGCAGGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.03 Da
• Isoelectric Point: 5.5535

>AT49110 WP_023637600.1 NZ_CP009460:c2061317-2061051 [Dickeya fangzhongdai]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT49110 NZ_CP009460:c2061317-2061051 [Dickeya fangzhongdai]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGCTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCATGGCGAGCCGGTGGATCCGGAGCTGAAGCGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K8QSU7