Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1928645..1929195 Replicon chromosome
Accession NZ_CP009460
Organism Dickeya fangzhongdai strain ND14b

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LH89_RS08125 Protein ID WP_038662017.1
Coordinates 1928645..1928953 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LH89_RS08130 Protein ID WP_027711205.1
Coordinates 1928956..1929195 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH89_RS08100 1924656..1925201 - 546 WP_049869971.1 S26 family signal peptidase -
LH89_RS08105 1925512..1926324 - 813 WP_049870085.1 replication initiator protein A -
LH89_RS08110 1926351..1926647 - 297 WP_038662009.1 helix-turn-helix domain-containing protein -
LH89_RS08115 1926731..1927528 - 798 WP_038662012.1 DUF2285 domain-containing protein -
LH89_RS08120 1927881..1928459 - 579 WP_123961375.1 hypothetical protein -
LH89_RS08125 1928645..1928953 - 309 WP_038662017.1 CcdB family protein Toxin
LH89_RS08130 1928956..1929195 - 240 WP_027711205.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LH89_RS23010 1929394..1929483 - 90 Protein_1636 DUF736 domain-containing protein -
LH89_RS08135 1929565..1929681 + 117 Protein_1637 transposase -
LH89_RS08140 1929907..1930923 - 1017 WP_038662027.1 IS110 family transposase -
LH89_RS08150 1930990..1931984 + 995 Protein_1639 IS3 family transposase -
LH89_RS08155 1932316..1932702 + 387 WP_038662036.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1874819..1987261 112442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11644.48 Da        Isoelectric Point: 5.0196

>T49109 WP_038662017.1 NZ_CP009460:c1928953-1928645 [Dickeya fangzhongdai]
MQYMVYRNNDNSRAYPYLLDVQSDIIGELHTRLVIPLFPEEKVNASVVKRLTPVLPVEGCDYLVMTHEMASVRLSQLGPQ
VMDAQPYRQSIKAALDFLLDGF

Download         Length: 309 bp

>T49109 NZ_CP009460:c1928953-1928645 [Dickeya fangzhongdai]
ATGCAGTACATGGTGTATCGCAATAACGATAACAGCAGGGCATACCCTTATCTGCTTGATGTGCAGAGTGATATCATCGG
GGAGCTGCATACACGCCTGGTTATCCCACTGTTCCCAGAGGAGAAGGTGAACGCCAGTGTGGTAAAACGCCTGACACCTG
TCTTACCGGTTGAGGGCTGTGATTATCTGGTGATGACGCATGAAATGGCCAGCGTCCGGCTTTCCCAGCTTGGTCCGCAA
GTGATGGATGCCCAGCCATATCGACAGAGTATCAAAGCGGCGCTGGACTTTTTGCTGGATGGGTTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8975.07 Da        Isoelectric Point: 6.4674

>AT49109 WP_027711205.1 NZ_CP009460:c1929195-1928956 [Dickeya fangzhongdai]
MPTTSIRHKKTVSVTLEPALLQQAREAGINLSATLAEALKREIRASEAEQWQRENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT49109 NZ_CP009460:c1929195-1928956 [Dickeya fangzhongdai]
ATGCCGACTACAAGCATACGACACAAAAAAACCGTCAGCGTCACACTGGAGCCCGCCTTGTTGCAGCAGGCCCGGGAGGC
GGGAATTAATCTCTCGGCCACGCTTGCTGAGGCCCTGAAGCGGGAAATTCGAGCGTCAGAAGCGGAACAGTGGCAGCGAG
AAAACCGCGCCGGCCTGCAGGAACTCAACCGTATCACGGATGAGCATGGCTTGCTGTCCGATGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References