Detailed information of TA system TA049106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 976422..977039
• Replicon: chromosome
• Accession: NZ_CP009460
• Organism: Dickeya fangzhongdai strain ND14b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2K8QKH7
• Locus tag: LH89_RS22015
• Protein ID: WP_071842437.1
• Coordinates: 976422..976625 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LH89_RS04205
• Protein ID: WP_038660076.1
• Coordinates: 976629..977039 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH89_RS04195	971696..974743	-	3048	WP_071842435.1	formate dehydrogenase-N subunit alpha	-
LH89_RS04200	975295..976350	+	1056	WP_038660073.1	MBL fold metallo-hydrolase	-
LH89_RS22015	976422..976625	+	204	WP_071842437.1	type II toxin-antitoxin system HicA family toxin	Toxin
LH89_RS04205	976629..977039	+	411	WP_038660076.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LH89_RS04210	977250..977891	-	642	WP_038660079.1	RraA family protein	-
LH89_RS04215	977924..978733	-	810	WP_038660082.1	ABC transporter ATP-binding protein	-
LH89_RS04220	978745..979776	-	1032	WP_038668643.1	iron ABC transporter permease	-
LH89_RS04225	979784..980806	-	1023	WP_081943068.1	iron ABC transporter permease	-
LH89_RS04230	980803..981720	-	918	WP_038660085.1	iron-siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7347.47 Da
• Isoelectric Point: 11.0566

>T49106 WP_071842437.1 NZ_CP009460:976422-976625 [Dickeya fangzhongdai]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGISSSLTQRG

Nucleotide

• Length: 204 bp

>T49106 NZ_CP009460:976422-976625 [Dickeya fangzhongdai]
ATGGATAGCAGGACGTTGATAGCAGAAATCAAGGCCGATGGATGGGAGCTGGTAAGGGTTAACGGCAGTCATCACCACTT
TACCCACCCAACCAAACCAGGATTAGTGACCATCCCACACCCTAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GAAAACAAGCGGGGATATCATCCTCACTAACTCAAAGAGGCTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14483.48 Da
• Isoelectric Point: 4.3494

>AT49106 WP_038660076.1 NZ_CP009460:976629-977039 [Dickeya fangzhongdai]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKEAITGHIELLIEMGQDIPAVSSVGALAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Nucleotide

• Length: 411 bp

>AT49106 NZ_CP009460:976629-977039 [Dickeya fangzhongdai]
ATGTTTTATCCAATTGCCATTGAAGCAGGTGACGATACTCATGCATACGGCGTGACAGTGCCCGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCTATCGCCAATGCTAAAGAAGCGATCACCGGCCATATTGAGCTGCTGATCGAGA
TGGGCCAGGATATTCCCGCCGTGTCATCCGTAGGTGCGCTGGCGAAAGCACCGGAGTACACCGGTTACACTTGGGCTGTT
GTTGATATTGATGTCACTCGGCTGATGGGAGGGGCGGAAAAAATCAACGTCACGCTGCCGAAGTCGCTGATTGACCGTAT
AGACCGCTGCGTAGCGAGTAACCCGGAATTTAAAAGCCGCTCAGGATTTCTTGCTCAGGCGGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Structures

Toxin

• AlphaFold DB: A0A2K8QKH7