Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4516766..4517384 Replicon chromosome
Accession NZ_CP009459
Organism Cedecea neteri strain ND14a

Toxin (Protein)


Gene name Hha Uniprot ID S3J5Z6
Locus tag LH86_RS21020 Protein ID WP_008460299.1
Coordinates 4517169..4517384 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X7LVC3
Locus tag LH86_RS21015 Protein ID WP_008460297.1
Coordinates 4516766..4517140 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH86_RS21005 4511831..4513030 + 1200 WP_039295998.1 efflux RND transporter periplasmic adaptor subunit -
LH86_RS21010 4513053..4516201 + 3149 Protein_4140 multidrug efflux RND transporter permease subunit AcrB -
LH86_RS21015 4516766..4517140 + 375 WP_008460297.1 Hha toxicity modulator TomB Antitoxin
LH86_RS21020 4517169..4517384 + 216 WP_008460299.1 hemolysin expression modulator Hha Toxin
LH86_RS21025 4517635..4518186 + 552 WP_039305524.1 maltose O-acetyltransferase -
LH86_RS21030 4518312..4518788 + 477 WP_008460303.1 YlaC family protein -
LH86_RS22360 4518792..4518932 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LH86_RS21035 4518936..4519196 - 261 WP_008460319.1 type B 50S ribosomal protein L31 -
LH86_RS21040 4519321..4521225 - 1905 WP_039305527.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8526.94 Da        Isoelectric Point: 9.4828

>T49096 WP_008460299.1 NZ_CP009459:4517169-4517384 [Cedecea neteri]
MTTKLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 216 bp

>T49096 NZ_CP009459:4517169-4517384 [Cedecea neteri]
ATGACTACCAAGCTCACTAAGACCGATTATTTGATGCGCCTGCGGCGTTGTCAGACAATTGATACGCTCGAACGCGTAAT
AGAAAAAAATAAATATGAATTATCAGATAATGAACTGGCGGTATTTTATTCAGCAGCTGACCACCGTCTTGCAGAACTGA
CGATGAATAAACTGTATGACAAAATCCCACCTTCAGTGTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14459.17 Da        Isoelectric Point: 5.1574

>AT49096 WP_008460297.1 NZ_CP009459:4516766-4517140 [Cedecea neteri]
MDEYSPKRHDIAQLKFLCESLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAASALNYKIKYPDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQRWRKSGNRLFRCFISESRANPVSHSF

Download         Length: 375 bp

>AT49096 NZ_CP009459:4516766-4517140 [Cedecea neteri]
ATGGACGAATACTCACCAAAGCGGCACGACATCGCGCAGCTTAAGTTCCTCTGTGAGAGTCTGTATCACGATTGTCTGAC
CAATCTTGGTGAGAGCAATCATGGGTGGGTTAATGATCCTACATCGGCCATTAATCTGCAGTTGAATGAATTGATTGAGC
ACATTGCTGCATCGGCGCTTAATTATAAAATTAAGTATCCGGATGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGTTATTTAGCAATTACGGCATTAACGCACAGGACTTGCAGCGGTGGCGTAAATCAGGGAATCGCTT
GTTCAGATGTTTCATCAGTGAGAGTCGCGCTAATCCTGTAAGCCACTCGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7LUT2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7LVC3

References