Detailed information of TA system TA049084

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 337891..338560
• Replicon: chromosome
• Accession: NZ_CP009459
• Organism: Cedecea neteri strain ND14a

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LH86_RS01595
• Protein ID: WP_039297862.1
• Coordinates: 337891..338313 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1X7KKT1
• Locus tag: LH86_RS01600
• Protein ID: WP_008461626.1
• Coordinates: 338294..338560 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH86_RS01575	333891..335624	-	1734	WP_039297852.1	single-stranded-DNA-specific exonuclease RecJ	-
LH86_RS01580	335631..336347	-	717	WP_039297854.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LH86_RS01585	336374..337270	-	897	WP_039297857.1	site-specific tyrosine recombinase XerD	-
LH86_RS01590	337373..337894	+	522	WP_039297860.1	flavodoxin FldB	-
LH86_RS01595	337891..338313	-	423	WP_039297862.1	protein YgfX	Toxin
LH86_RS01600	338294..338560	-	267	WP_008461626.1	FAD assembly factor SdhE	Antitoxin
LH86_RS01605	338807..339793	+	987	WP_039297865.1	tRNA-modifying protein YgfZ	-
LH86_RS01610	339852..340505	-	654	WP_039297867.1	hemolysin III family protein	-
LH86_RS01615	340680..341273	+	594	WP_039297870.1	HD domain-containing protein	-
LH86_RS01620	341316..342044	+	729	WP_039297872.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16502.45 Da
• Isoelectric Point: 11.7122

>T49084 WP_039297862.1 NZ_CP009459:c338313-337891 [Cedecea neteri]
VVLWQSDLRVSWRAQWMSLLLHGLVALFVLLMPWPMSYTLVWMLLLSLVVFDSVRSQRRIHARQGEIKLLADFRLRWQGR
DWDIVGNPWLIDSGAMLRLRRAGKHRCQHLWLAADSMDIGEWRDLRRLLMQQQASGSGQI

Nucleotide

• Length: 423 bp

>T49084 NZ_CP009459:c338313-337891 [Cedecea neteri]
GTGGTCCTGTGGCAATCTGATCTCCGGGTTTCCTGGCGCGCGCAATGGATGTCATTGCTCCTCCACGGCCTGGTGGCGCT
GTTCGTGCTGCTAATGCCGTGGCCGATGAGCTATACGCTCGTCTGGATGCTGCTGCTTTCCCTTGTGGTTTTCGACAGCG
TACGCAGCCAGCGCCGTATTCACGCTCGCCAGGGCGAAATTAAACTGCTGGCGGACTTTCGCCTGCGCTGGCAGGGGCGT
GACTGGGATATCGTCGGAAATCCGTGGCTTATTGACAGCGGGGCGATGCTAAGACTGCGTCGTGCCGGAAAACATCGTTG
CCAGCATCTTTGGCTGGCAGCTGACAGCATGGATATCGGTGAATGGCGAGATCTACGCCGCCTGCTGATGCAGCAACAGG
CGAGCGGAAGCGGGCAGATTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10385.88 Da
• Isoelectric Point: 5.6202

>AT49084 WP_008461626.1 NZ_CP009459:c338560-338294 [Cedecea neteri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYETLSDSDKQLFVRLLESDDPDLFNWLMNHGKPADAELQRMVALIQTRN
KERGPVAI

Nucleotide

• Length: 267 bp

>AT49084 NZ_CP009459:c338560-338294 [Cedecea neteri]
ATGGATATCAATAATAAAGCCCGAATTCACTGGGCATGCCGCCGTGGAATGCGCGAGCTCGATATTTCGATTATGCCGTT
CTTCGAACATGAATATGAAACGCTCAGCGACAGCGATAAGCAGCTGTTTGTTCGCCTGCTAGAGTCAGACGATCCAGACC
TGTTTAACTGGTTGATGAACCACGGTAAACCAGCAGATGCCGAGCTTCAGCGTATGGTTGCCCTGATTCAGACACGGAAT
AAAGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1X7KKT1