Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 116022..116819 Replicon chromosome
Accession NZ_CP009459
Organism Cedecea neteri strain ND14a

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LH86_RS00515 Protein ID WP_039297445.1
Coordinates 116022..116546 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag LH86_RS00520 Protein ID WP_039297448.1
Coordinates 116550..116819 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH86_RS00500 111239..114391 + 3153 WP_039297439.1 multidrug efflux RND transporter permease subunit OqxB -
LH86_RS00505 114492..114971 - 480 WP_008458195.1 Rrf2 family transcriptional regulator -
LH86_RS00510 115264..115848 - 585 WP_039297442.1 hypothetical protein -
LH86_RS00515 116022..116546 - 525 WP_039297445.1 GNAT family N-acetyltransferase Toxin
LH86_RS00520 116550..116819 - 270 WP_039297448.1 DUF1778 domain-containing protein Antitoxin
LH86_RS00525 117111..118031 + 921 WP_039297451.1 curved DNA-binding protein -
LH86_RS00530 118031..118336 + 306 WP_039297454.1 chaperone modulator CbpM -
LH86_RS00535 118486..118845 + 360 WP_039286956.1 hypothetical protein -
LH86_RS00540 118893..119678 - 786 WP_039297457.1 helix-turn-helix transcriptional regulator -
LH86_RS00545 119771..120637 + 867 WP_039297460.1 EamA family transporter -
LH86_RS00550 120634..121314 - 681 WP_039297463.1 nitroreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19400.13 Da        Isoelectric Point: 7.9458

>T49082 WP_039297445.1 NZ_CP009459:c116546-116022 [Cedecea neteri]
VADLTIELFSADTAYDFRGFDCGETSLNAFLGEHFIRQHNGRFLRGYLLVTKDVNPKVLGYYTLSGSCFEKEALPSNTQK
RKIPYANVPSVTLGRLAIHKDLQGQEWGSALVAHAMKVVYLASQAVGVHGIFVDAINDNAKHFYQKLGFIALVGKNANSL
FYPTRSIEKLFEHE

Download         Length: 525 bp

>T49082 NZ_CP009459:c116546-116022 [Cedecea neteri]
GTGGCCGACCTGACTATTGAATTGTTTTCAGCAGATACCGCCTATGATTTTCGCGGTTTTGACTGCGGAGAAACGTCTCT
GAATGCTTTTCTCGGCGAACACTTTATTCGCCAGCACAATGGCCGCTTTTTACGTGGCTATCTTCTTGTGACCAAAGATG
TAAATCCCAAAGTGCTGGGTTACTACACCTTATCCGGCAGCTGCTTTGAAAAAGAGGCGCTGCCGTCGAACACCCAAAAA
CGAAAAATCCCCTATGCAAATGTCCCCAGCGTGACGCTGGGGCGGCTGGCCATTCATAAAGATCTGCAGGGTCAGGAATG
GGGTTCAGCGCTTGTGGCGCACGCAATGAAAGTGGTTTATTTAGCGTCACAGGCGGTGGGCGTTCATGGGATTTTTGTCG
ATGCCATTAACGATAATGCGAAGCACTTTTATCAAAAATTAGGCTTTATTGCGCTGGTAGGGAAAAACGCTAATTCGCTT
TTTTATCCTACCAGGTCGATTGAAAAATTATTTGAGCATGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10170.64 Da        Isoelectric Point: 6.9832

>AT49082 WP_039297448.1 NZ_CP009459:c116819-116550 [Cedecea neteri]
MSALKKQRIDLRLSDDDKSMIEEAAAMSNQTITQFMIACASARAAEVIEQHRRLVLNEASWNRVMDAISNPPEPDDRLKR
AARRLKDME

Download         Length: 270 bp

>AT49082 NZ_CP009459:c116819-116550 [Cedecea neteri]
ATGTCAGCTTTAAAAAAACAGCGCATCGACCTCAGATTGAGTGACGACGACAAAAGCATGATCGAAGAGGCGGCAGCCAT
GTCCAATCAGACGATCACCCAGTTTATGATTGCCTGTGCGTCGGCGCGCGCTGCGGAAGTGATCGAACAGCATCGCCGCC
TGGTGCTGAATGAAGCATCGTGGAACCGAGTGATGGATGCTATTAGTAATCCGCCTGAACCGGATGACAGGCTAAAACGT
GCAGCAAGGCGTCTGAAAGACATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References