Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4823090..4823707 Replicon chromosome
Accession NZ_CP009458
Organism Cedecea neteri strain M006

Toxin (Protein)


Gene name Hha Uniprot ID S3J5Z6
Locus tag LH23_RS22375 Protein ID WP_008460299.1
Coordinates 4823492..4823707 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X7LVC3
Locus tag LH23_RS22370 Protein ID WP_008460297.1
Coordinates 4823090..4823464 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH23_RS22360 4818154..4819353 + 1200 WP_039295998.1 efflux RND transporter periplasmic adaptor subunit -
LH23_RS22365 4819376..4822525 + 3150 WP_039295999.1 multidrug efflux RND transporter permease subunit -
LH23_RS22370 4823090..4823464 + 375 WP_008460297.1 Hha toxicity modulator TomB Antitoxin
LH23_RS22375 4823492..4823707 + 216 WP_008460299.1 hemolysin expression modulator Hha Toxin
LH23_RS22380 4823959..4824510 + 552 WP_039296002.1 maltose O-acetyltransferase -
LH23_RS22385 4824637..4825113 + 477 WP_039296004.1 YlaC family protein -
LH23_RS22390 4825117..4825257 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LH23_RS22395 4825261..4825521 - 261 WP_008460319.1 type B 50S ribosomal protein L31 -
LH23_RS22400 4825646..4827550 - 1905 WP_039296008.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8526.94 Da        Isoelectric Point: 9.4828

>T49081 WP_008460299.1 NZ_CP009458:4823492-4823707 [Cedecea neteri]
MTTKLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 216 bp

>T49081 NZ_CP009458:4823492-4823707 [Cedecea neteri]
ATGACTACCAAGCTCACTAAGACCGATTATTTGATGCGCCTGCGGCGTTGTCAGACAATTGATACGCTGGAACGCGTAAT
AGAAAAAAATAAATATGAATTATCAGATAATGAACTGGCGGTATTTTATTCAGCAGCCGACCACCGTCTTGCAGAACTGA
CGATGAATAAACTGTATGATAAAATCCCACCTTCAGTGTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14459.17 Da        Isoelectric Point: 5.1574

>AT49081 WP_008460297.1 NZ_CP009458:4823090-4823464 [Cedecea neteri]
MDEYSPKRHDIAQLKFLCESLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAASALNYKIKYPDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQRWRKSGNRLFRCFISESRANPVSHSF

Download         Length: 375 bp

>AT49081 NZ_CP009458:4823090-4823464 [Cedecea neteri]
ATGGACGAATACTCACCAAAGCGGCACGACATCGCGCAGCTTAAGTTCCTCTGTGAGAGTCTGTATCACGATTGTCTGAC
CAATCTTGGTGAGAGCAATCATGGGTGGGTTAATGATCCTACATCGGCCATTAATCTACAGTTGAATGAATTGATTGAGC
ACATTGCTGCATCGGCGCTTAATTATAAGATTAAGTATCCAGATGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGTTATTTAGCAATTACGGCATTAACGCACAGGACTTGCAGCGGTGGCGTAAATCAGGGAATCGCTT
GTTCAGATGTTTCATCAGTGAGAGTCGCGCTAACCCAGTAAGCCACTCGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7LUT2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7LVC3

References