Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4799795..4801354 Replicon chromosome
Accession NZ_CP009458
Organism Cedecea neteri strain M006

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LH23_RS22280 Protein ID WP_039295963.1
Coordinates 4799795..4801105 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LH23_RS22285 Protein ID WP_039295966.1
Coordinates 4801106..4801354 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH23_RS22265 4794804..4796456 - 1653 WP_039295954.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA -
LH23_RS22270 4796645..4797862 + 1218 WP_039295958.1 MFS transporter -
LH23_RS22275 4798080..4799756 + 1677 WP_039295960.1 Kef family K(+) transporter -
LH23_RS22280 4799795..4801105 - 1311 WP_039295963.1 type II toxin-antitoxin system HipA family toxin Toxin
LH23_RS22285 4801106..4801354 - 249 WP_039295966.1 helix-turn-helix domain-containing protein Antitoxin
LH23_RS22290 4801613..4802917 - 1305 WP_039295969.1 inosine/guanosine kinase -
LH23_RS22295 4802978..4803943 - 966 WP_039295971.1 ferrochelatase -
LH23_RS22300 4804078..4804722 - 645 WP_008460251.1 adenylate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49500.63 Da        Isoelectric Point: 5.7602

>T49080 WP_039295963.1 NZ_CP009458:c4801105-4799795 [Cedecea neteri]
MKRLSVYMNGYLVGQLVQENSGSNIFQYDHQWVKMPGARPISLSMPLRIAEYTGEVVFNFFDNLLPDNRDIRERIASRYH
ADSLQPFDLLYEVGRDCVGALILQPPQEAIQNIEQINSEMLDAEKLDAILMGYLNPSRYLQQETYDFRISIAGAQEKTAL
LRYQNDWQLPKGITPTTHIFKLPVGEIQGHSFTLDLRDSVENEWLCMQLAGLYGLKVPTCEIITTRNIKALAVERFDRRF
VDNNRWIARLPQEDICQALGFPSTKKYESDGGPGIEPIMKFLLGSDNAEQDRENFMRSHILFWLLAASDGHAKNYSVGIM
PGGGYSLTPLYDIMSCYPLIGGRGLAKQDIKMAMSLASTEKGRKYEWNTIFPRNFLATARKCGFSETRMSELIDEFYQKT
PAVLSEAKALLPKNFPESISDAIFNGVENASRRLAL

Download         Length: 1311 bp

>T49080 NZ_CP009458:c4801105-4799795 [Cedecea neteri]
ATGAAGCGTTTATCTGTGTATATGAATGGGTATTTGGTGGGGCAATTAGTACAGGAGAATAGCGGTTCTAATATTTTTCA
GTACGATCATCAGTGGGTTAAGATGCCGGGTGCGCGTCCAATATCACTTTCCATGCCGTTACGCATAGCAGAATATACAG
GTGAAGTTGTTTTTAACTTTTTCGACAACCTGCTGCCGGATAATCGTGACATTCGTGAGCGGATCGCCAGCCGTTATCAC
GCTGACTCTCTACAGCCCTTTGATTTACTTTATGAAGTGGGTCGTGACTGTGTCGGGGCATTAATATTACAGCCGCCGCA
AGAAGCCATTCAGAACATAGAGCAGATAAACAGTGAAATGCTTGATGCGGAAAAGTTGGACGCCATTCTTATGGGCTATT
TAAATCCTTCCCGGTATCTTCAGCAAGAAACGTATGACTTTCGTATTTCAATTGCGGGTGCACAGGAAAAAACGGCATTA
CTGCGTTATCAGAATGACTGGCAATTGCCTAAAGGCATTACACCCACTACACACATATTTAAGTTGCCGGTTGGCGAAAT
CCAGGGGCACAGTTTTACGTTGGATCTTCGTGATAGCGTGGAAAATGAATGGCTTTGCATGCAGCTGGCAGGGTTGTATG
GTCTGAAAGTTCCAACATGCGAAATCATCACAACCCGTAACATTAAGGCTCTGGCCGTGGAGCGTTTCGATCGCCGTTTT
GTGGATAATAACCGCTGGATTGCCCGGCTTCCGCAGGAGGATATTTGCCAGGCTTTAGGTTTTCCATCGACGAAAAAATA
TGAAAGCGACGGCGGGCCGGGCATAGAACCTATTATGAAATTTCTGCTGGGTTCAGATAATGCGGAGCAGGACCGGGAAA
ATTTTATGCGCAGTCATATTCTTTTCTGGTTACTGGCGGCAAGTGATGGCCATGCAAAAAACTATTCTGTTGGTATTATG
CCAGGTGGTGGATATAGCCTGACGCCTCTATATGACATTATGTCCTGTTATCCACTTATTGGCGGGCGTGGACTTGCGAA
ACAAGATATAAAAATGGCGATGTCGCTGGCATCCACCGAAAAGGGCAGAAAATATGAGTGGAATACTATTTTTCCCCGCA
ACTTTCTCGCAACGGCTAGAAAATGTGGTTTTAGTGAAACAAGAATGTCGGAACTTATAGACGAGTTTTATCAAAAAACG
CCAGCAGTCCTGAGTGAAGCGAAAGCATTACTGCCGAAAAACTTTCCAGAGTCTATCAGCGATGCCATCTTTAATGGCGT
GGAAAACGCCAGCCGACGACTGGCATTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9340.61 Da        Isoelectric Point: 7.0137

>AT49080 WP_039295966.1 NZ_CP009458:c4801354-4801106 [Cedecea neteri]
MKITSPDQLAIFLKDARKQGKQTQESVAEKVGLRQDTVSKFENNPAKTQIDTLFKILSSMNMELHIEAKSSQGSSEVWKE
EW

Download         Length: 249 bp

>AT49080 NZ_CP009458:c4801354-4801106 [Cedecea neteri]
ATGAAAATCACTTCCCCGGATCAATTGGCTATTTTCCTGAAGGATGCTCGCAAACAGGGTAAGCAAACACAGGAGTCAGT
GGCAGAGAAAGTCGGTTTACGGCAGGATACCGTCTCAAAATTTGAGAACAACCCAGCCAAAACTCAGATTGATACATTAT
TTAAAATACTATCGTCTATGAATATGGAGCTTCATATTGAGGCGAAATCCAGCCAGGGGAGCTCTGAAGTCTGGAAAGAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References